CAS 1206456-44-1

Olopatadine Isopropyl ester Hydrochloride

Description:

Olopatadine Isopropyl ester Hydrochloride is a chemical compound primarily known for its application as an antihistamine, particularly in the treatment of allergic conjunctivitis. It is a derivative of olopatadine, which is a selective histamine H1 receptor antagonist. The compound exhibits properties that help alleviate symptoms associated with allergic reactions, such as itching and redness in the eyes. In terms of its chemical characteristics, it is typically presented as a white to off-white crystalline powder, soluble in water and various organic solvents, which facilitates its formulation in pharmaceutical preparations. The hydrochloride salt form enhances its stability and bioavailability. The compound's mechanism of action involves the inhibition of histamine release from mast cells, thereby reducing the inflammatory response. Additionally, it may possess some anti-inflammatory properties, contributing to its effectiveness in treating allergic conditions. As with any pharmaceutical substance, proper handling and adherence to safety guidelines are essential during its use and formulation.

Formula: C₂₄H₂₉NO₃

Synonyms:

• Olopatadine Isopropyl ester
• Olopatadine Impurity C: Z Olopatadine Isopropyl Hydrochloride
• (Z)-Isopropyl 2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)Acetate
• Olopatadine (E)-Isopropyl ester
• Dibenz[b,e]oxepin-2-acetic acid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, 1-methylethyl ester, (11Z)-
• Olopatadine Isopropyl ester Hydrochloride
• Olopatadine Impurity 7
• Olopatadine Isopropyl Este

Olopatadine Isopropyl Ester HCl

CAS: 1206456-44-1

Formula: C₂₄H₂₉NO₃·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 379.50 36.46

Ref: 4Z-O-1014

Olopatadine Isopropyl Ester

Controlled Product

CAS: 1206456-44-1

Formula: C₂₄H₂₉NO₃

Color and Shape: Neat

Molecular weight: 379.49

Ref: 86-MM1261.08

Olopatadine Isopropyl ester

CAS: 1206456-44-1

Formula: C₂₄H₂₉NO₃

Molecular weight: 379.49

Ref: ST-EA-CP-O8004

Olopatadine Isopropyl Ester

Controlled Product

CAS: 1206456-44-1

Applications Olopatadine Isopropyl Ester is an intermediate used to prepare Olopatadine (O575000, HCl salt) via Wittig reaction. Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer.
References Kamei, C., et al.: Arzneim.-Forsch., 45, 1005 (1995); Sharif, N.A., et al.: J. Pharmacol. Exp. Ther., 278, 1252 (1996); Abelson, M.B., et al.: Am. J. Ophthalmol., 125, 797 (1998); Silva, G., et al.: Eur. Pat. Appl., EP 2145882 A1 20100120 (2010)

Formula: C₂₄H₂₉NO₃

Color and Shape: Colourless To Light Yellow

Molecular weight: 379.49

Ref: TR-O575025

Olopatadine Isopropyl Ester-d6

Controlled Product

CAS: 1206456-44-1

Applications Olopatadine Isopropyl Ester-d6 is labelled Olopatadine Isopropyl Ester (O575025), an intermediate used to prepare Olopatadine (O575000, HCl salt) via Wittig reaction. Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer.
References Kamei, C., et al.: Arzneim.-Forsch., 45, 1005 (1995); Sharif, N.A., et al.: J. Pharmacol. Exp. Ther., 278, 1252 (1996); Abelson, M.B., et al.: Am. J. Ophthalmol., 125, 797 (1998); Silva, G., et al.: Eur. Pat. Appl., EP 2145882 A1 20100120 (2010)

Formula: C₂₄D₆H₂₃NO₃

Color and Shape: Neat

Molecular weight: 385.529

Ref: TR-O575027