CAS 120685-11-2

4'-N-benzoylstaurosporine

Description:

4'-N-benzoylstaurosporine, with the CAS number 120685-11-2, is a synthetic compound derived from staurosporine, a natural alkaloid known for its potent inhibitory effects on protein kinases. This compound features a benzoyl group attached to the nitrogen atom at the 4' position of the staurosporine structure, which enhances its biological activity and selectivity. It is characterized by its complex polycyclic structure, which contributes to its ability to interact with various biological targets. 4'-N-benzoylstaurosporine exhibits significant anti-cancer properties, making it a subject of interest in pharmacological research. Its mechanism of action primarily involves the inhibition of specific kinases, which play crucial roles in cell signaling pathways related to growth and proliferation. Additionally, this compound is often studied for its potential in treating various diseases, including cancer, due to its ability to induce apoptosis in malignant cells. As with many chemical substances, safety and handling precautions are essential due to its bioactive nature.

Formula: C₃₅H₃₀N₄O₄

InChI: InChI=1/C35H30N4O4/c1-34(42-4)30(37(3)32(41)19-12-6-5-7-13-19)33-38-23-16-10-8-14-20(23)26-27-22(18-36-31(27)40)25-21-15-9-11-17-24(21)39(29(25)28(26)38)35(34,2)43-33/h5-17,30,33H,18H2,1-4H3,(H,36,40)/t30-,33-,34-,35+/m1/s1

InChI key: InChIKey=BMGQWWVMWDBQGC-IIFHNQTCSA-N

SMILES: C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@H](N(C(=O)C9=CC=CC=C9)C)[C@H]2OC)[H])=CC=CC8

Synonyms:

• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonine, benzamide deriv.
• Benzamide, N-(2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-, [9S-(9α,10β,11β,13α)]-
• Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
• Benzoylstaurosporine
• Cgp 41231
• Cgp 41251
• Midostaurin
• N-Benzoylstaurosporine
• N-[(5R,6S,7R,8S)-7-methoxy-7,8-dimethyl-15-oxo-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacen-6-yl]-N-methylbenzamide
• N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide
• Pkc 412
• Rydapt
• PKC412
• Midostaurin(PKC412)
• PKC412 from Staurosporine
• Benzamide, N-(2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-1-oxo-8,12-epoxy-1H,8H-2,7B,12A-triazadibenzo(A,G)cyclonona(cde)trinden-10-yl)-N-methyl-, (8alpha,9beta,10beta,12alpha)-
• CS-730
• Midostaurin, Benzoylstaurosporine, 4'-N-Benzoylstaurosporine, CGP 41251
• (Midostaurin) Benzoylstaurosporine
• [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide
• PKC412 (Midostaurin)
• Midostaurin USP/EP/BP
• Cgp 41 251
• Midostaurin [inn]
• MIDOSTAURIN; CGP-41251; PKC-412; PKC412;PKC 412
• PKC412(Midostaurin,CGP41231,CGP41251)
• Staurosporine, N-Benzoyl
• QTH113
• PKC412 CGP 41231 CGP 41251 Midostaurin Benzoylstaurosporine
• Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
• Midaustorin
• midostaruin
• N-((5S,6R,7R,9R)-6-Methoxy-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-Methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-MethylbenzaMide
• Benzamide, N-((9S,10R,11R,13R)-2,3,9,10,11,12-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-J)(1,7)benzodiazonin-11-yl)-N-methyl-
• PKC-412, CGP-41251
• CGP 41251MIDOSTAURIN(PKC412)
• MIDOSTAURIN (PKC412; CGP 41251)

N-Benzoylstaurosporine

CAS: 120685-11-2

Formula: C₃₅H₃₀N₄O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 570.6371

Ref: IN-DA00386D

PKC412

CAS: 120685-11-2

PKC412

Color and Shape: Off-White Powder

Molecular weight: 570.64g/mol

Ref: 54-BIP1007

Midostaurin

CAS: 120685-11-2

Midostaurin

Purity: ≥95%

Molecular weight: 570.64g/mol

Ref: 54-BUP12418

Midostaurin

CAS: 120685-11-2

Formula: C₃₅H₃₀N₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 570.65

Ref: 4Z-M-160001

Midostaurin-d5

CAS: 120685-11-2

Formula: C₃₅H₂₅D₅N₄O₄

Color and Shape: Off-White Solid

Molecular weight: 575.68

Ref: 4Z-M-160004

Midostaurin

CAS: 120685-11-2

PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.

Formula: C₃₅H₃₀N₄O₄

Purity: 97.61% - >99.99%

Color and Shape: Solid

Molecular weight: 570.64

Ref: TM-T3211

Midostaurin-13C6

Controlled Product

CAS: 120685-11-2

Stability Hygroscopic
Applications Midostaurin-13C6 is the labelled analogue of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Formula: C₂₉C₆H₃₀N₄O₄

Color and Shape: Neat

Molecular weight: 576.59

Ref: TR-M343762

Midostaurin-D5

Controlled Product

CAS: 120685-11-2

Formula: C₃₅D₅H₂₅N₄O₄

Color and Shape: Neat

Molecular weight: 575.668

Ref: TR-M343764

Midostaurin

CAS: 120685-11-2

Stability Hygroscopic
Applications Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Formula: C₃₅H₃₀N₄O₄

Color and Shape: Neat

Molecular weight: 570.64

Ref: TR-M343760

PKC 412

CAS: 120685-11-2

Inhibits multiple protein kinases, such as PKC and FLT3

Formula: C₃₅H₃₀N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 570.64 g/mol

Ref: 3D-FP43194

N-Benzoyloxy Midostaurin

Controlled Product

CAS: 120685-11-2

Formula: C₃₅H₃₀O₅N₄

Color and Shape: Neat

Molecular weight: 586.65

Ref: TR-B208086