CAS 120685-11-2: 4'-N-benzoylstaurosporine
Description:4'-N-benzoylstaurosporine, with the CAS number 120685-11-2, is a synthetic compound derived from staurosporine, a natural alkaloid known for its potent inhibitory effects on protein kinases. This compound features a benzoyl group attached to the nitrogen atom at the 4' position of the staurosporine structure, which enhances its biological activity and selectivity. It is characterized by its complex polycyclic structure, which contributes to its ability to interact with various biological targets. 4'-N-benzoylstaurosporine exhibits significant anti-cancer properties, making it a subject of interest in pharmacological research. Its mechanism of action primarily involves the inhibition of specific kinases, which play crucial roles in cell signaling pathways related to growth and proliferation. Additionally, this compound is often studied for its potential in treating various diseases, including cancer, due to its ability to induce apoptosis in malignant cells. As with many chemical substances, safety and handling precautions are essential due to its bioactive nature.
Formula:C35H30N4O4
InChI:InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1
InChI key:InChIKey=BMGQWWVMWDBQGC-IIFHNQTCSA-N
SMILES:O=C1NCC=2C1=C3C4=CC=CC=C4N5C3=C6C2C=7C=CC=CC7N6C8(OC5CC(N(C(=O)C=9C=CC=CC9)C)C8OC)C
- Synonyms:
- 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonine, benzamide deriv.
- Benzamide, N-(2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-, [9S-(9α,10β,11β,13α)]-
- Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
- Benzoylstaurosporine
- Cgp 41231
- Cgp 41251
- Midostaurin
- N-Benzoylstaurosporine
- N-[(5R,6S,7R,8S)-7-methoxy-7,8-dimethyl-15-oxo-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacen-6-yl]-N-methylbenzamide
- N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide
- See more synonyms
- Pkc 412
- Rydapt
- PKC412
- Midostaurin(PKC412)
