CAS 1207258-55-6

NVS-CRF-38

CAS: 1207258-55-6

NVS-CRF-38 is a corticotropin-releasing factor (CRF) analog. It is a conjugated form of the CRF-III peptide, which has been modified to contain a phenylalanine residue at position 3 and an arginine residue at position 9. The test compound binds to the CRF receptor and acts as a partial agonist. NVS-CRF-38 has been shown to have pharmacokinetic properties similar to those of native CRF in rats and humans. In rats, plasma protein binding was ˜80% with no effect by deuterium isotope on drug pharmacokinetics. In humans, it was found that NVS-CRF-38 had high oral bioavailability and good absorption in the small intestine.

Formula: C₁₉H₂₁N₅O₂

Purity: Min. 95%

Molecular weight: 351.4 g/mol

Ref: 3D-HYB25855

NVS-CRF38

CAS: 1207258-55-6

NVS-CRF38 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1).

Formula: C₁₉H₂₁N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 351.4

Ref: TM-T12276