CAS 1207360-89-1

GDC-0349

Description:

GDC-0349, with the CAS number 1207360-89-1, is a small molecule inhibitor primarily targeting the Hedgehog signaling pathway, which plays a crucial role in cell growth and differentiation. This compound has been investigated for its potential therapeutic applications in treating various cancers, particularly those associated with aberrant Hedgehog signaling, such as basal cell carcinoma and medulloblastoma. GDC-0349 exhibits selective inhibition of Smoothened (SMO), a key component of the Hedgehog pathway, thereby disrupting the signaling cascade that promotes tumor growth. The substance is characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. In preclinical studies, GDC-0349 has shown promising antitumor activity, leading to its evaluation in clinical trials. As with many investigational drugs, its safety profile, efficacy, and optimal dosing regimens are subjects of ongoing research.

(S)-1-Ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea

CAS: 1207360-89-1

Formula: C₂₄H₃₂N₆O₃

Purity: 98%

Molecular weight: 452.5493

Ref: IN-DA008TGC

GDC-0349

CAS: 1207360-89-1

GDC-0349

Purity: ≥95%

Molecular weight: 452.55g/mol

Ref: 54-BUP13147

GDC-0349

CAS: 1207360-89-1

GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.

Formula: C₂₄H₃₂N₆O₃

Purity: 96.00% - 98.49%

Color and Shape: Solid

Molecular weight: 452.55

Ref: TM-T6510