CAS 1207454-56-5

LT-673

CAS: 1207454-56-5

Formula: C₁₉H₁₄F₂N₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 380.3509

Ref: IN-DA008WLG

BMN 673-13C,15N2

Controlled Product

CAS: 1207454-56-5

Formula: CC₁₈H₁₄F₂₁₅N₂N₄O

Color and Shape: Neat

Molecular weight: 383.33

Ref: TR-B595898

BMN 673-d4

Controlled Product

CAS: 1207454-56-5

Formula: C₁₉D₄H₁₀F₂N₆O

Color and Shape: Neat

Molecular weight: 384.375

Ref: TR-B595897

BMN 673

Controlled Product

CAS: 1207454-56-5

Formula: C₁₉H₁₄F₂N₆O

Color and Shape: Neat

Molecular weight: 380.351

Ref: TR-B595895

(rac)-Talazoparib

CAS: 1207454-56-5

(rac)-Talazoparib ((rac)-BMN-673) (Compound 47) is an orally active inhibitor of PARP1/2, with Ki values of 1.2 nM and 0.87 nM, respectively. It inhibits cellular PARylation at an EC50 of 2.51 nM. This compound leads to the accumulation of DNA damage and suppresses the proliferation of BRCA1/2-mutated MX-1 and Capan-1 cells, with IC50 values of 0.3 nM and 5 nM, respectively. Additionally, (rac)-Talazoparib exhibits antitumor activity in mouse models.

Formula: C₁₉H₁₄F₂N₆O

Color and Shape: Solid

Molecular weight: 380.351

Ref: TM-T204239