CAS 1207456-00-5: S-Talazoparib

Description: S-Talazoparib, with the CAS number 1207456-00-5, is a potent and selective inhibitor of poly (ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair processes. This compound is primarily utilized in cancer therapy, particularly for treating certain types of breast and ovarian cancers associated with BRCA1 and BRCA2 mutations. S-Talazoparib exhibits a high affinity for the PARP enzyme, leading to the accumulation of DNA damage in cancer cells, ultimately inducing cell death. The substance is characterized by its small molecular weight and specific structural features that enhance its binding to the PARP active site. It is typically administered orally and has been studied for its efficacy in combination with other therapeutic agents. As a member of the class of PARP inhibitors, S-Talazoparib represents a significant advancement in targeted cancer treatment, offering a mechanism that exploits the deficiencies in DNA repair pathways present in certain tumors. Its development reflects ongoing research into personalized medicine approaches in oncology.

(8R,9S)-Talazoparib

CAS: 1207456-00-5

(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: …

• Formula: C₁₉H₁₄F₂N₆O
• Color and Shape: Solid
• Molecular weight: 380.35

BMN 673 (8R,9S)

CAS: 1207456-00-5

• Formula: C₁₉H₁₄F₂N₆O
• Purity: 98.36%
• Molecular weight: 380.3509

(8R,9S)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one

CAS: 1207456-00-5

Talazoparib is a potent DNA methyltransferase inhibitor that has been shown to inhibit the activity …

• Formula: C₁₉H₁₄F₂N₆O
• Purity: Min. 95%
• Molecular weight: 380.35 g/mol