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CAS 1207456-01-6

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Talazoparib

Description:
Talazoparib is a potent and selective inhibitor of poly (ADP-ribose) polymerase (PARP), primarily used in the treatment of certain types of cancer, particularly breast cancer associated with BRCA1 and BRCA2 mutations. It is classified as a small molecule drug and is known for its ability to interfere with DNA repair mechanisms, thereby enhancing the effectiveness of chemotherapy and radiation therapy in cancer cells. Talazoparib exhibits high affinity for PARP enzymes, leading to the accumulation of DNA damage in cancer cells, which ultimately triggers apoptosis. The compound is typically administered orally and has a favorable pharmacokinetic profile, allowing for effective systemic exposure. Its chemical structure includes a bicyclic core, contributing to its biological activity. Talazoparib has been evaluated in clinical trials, demonstrating significant antitumor activity and a manageable safety profile, making it a valuable option in targeted cancer therapy. As with any medication, monitoring for potential side effects and interactions is essential during treatment.
Formula:C19H14F2N6O
InChI:InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1
InChI key:InChIKey=HWGQMRYQVZSGDQ-HZPDHXFCSA-N
SMILES:CN1C([C@H]2C=3C4=C(N[C@@H]2C5=CC=C(F)C=C5)C=C(F)C=C4C(=O)NN3)=NC=N1
Synonyms:
  • (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one
  • 3H-Pyrido[4,3,2-de]phthalazin-3-one, 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-, (8S,9R)-
  • 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-Pyrido[4,3,2-de]phthalazin-3-one
  • Bmn-673
  • Bmn673
  • Talazoparib
  • Talzenna
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Found 5 products.