LDV FITC, or LDV fluorescein isothiocyanate, is a fluorescent dye commonly used in biochemical and cellular research. It is characterized by its ability to bind specifically to certain proteins, particularly those containing the LDV (Leu-Asp-Val) motif, which is often found in integrins. This specificity makes it a valuable tool for studying cell adhesion and migration. The compound exhibits strong fluorescence properties, allowing for easy visualization under a fluorescence microscope. Its structure includes a fluorescein moiety, which contributes to its bright green fluorescence, and an isothiocyanate group that facilitates covalent bonding to amino groups in proteins. LDV FITC is typically used in various applications, including immunofluorescence, flow cytometry, and live-cell imaging, enabling researchers to track cellular processes in real-time. Safety precautions should be taken when handling this compound, as with any chemical reagent, to avoid potential hazards associated with its use.

Fluorescent ligand that binds to theα4β1integrin (VLA-4) with high affinity (Kdvalues are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+respectively). Used to detect VLA-4 affinity and conformational changes.

LDV FITC

1207610-07-8: LDV FITC, or LDV fluorescein isothiocyanate, is a fluorescent dye commonly used in biochemical and cellular research. It is characterized by its ability to bind specifically to certain proteins, particularly those containing the LDV (Leu-Asp-Val) motif, which is often found in integrins. This specificity makes it a valuable tool for studying cell adhesion and migration. The compound exhibits strong fluorescence properties, allowing for easy visualization under a fluorescence microscope. Its structure includes a fluorescein moiety, which contributes to its bright green fluorescence, and an isothiocyanate group that facilitates covalent bonding to amino groups in proteins. LDV FITC is typically used in various applications, including immunofluorescence, flow cytometry, and live-cell imaging, enabling researchers to track cellular processes in real-time. Safety precautions should be taken when handling this compound, as with any chemical reagent, to avoid potential hazards associated with its use.

<p>fluorescent ligand that binds to the α4β1 integrin (VLA-4)</p>

<p>LDV FITC is a monoclonal antibody that binds to the extracellular domain of the human CD4 molecule. It is expressed as a heterodimer and has been shown to inhibit kinase signaling pathways in human lymphocytes. LDV FITC is used in cell-binding assays to detect the presence of CD4 molecules on cells and can be used to screen for HIV-1 antibodies. LDV FITC has also been shown to be effective against ischemia/reperfusion injury in rat hearts.</p>

CAS 1207610-07-8

LDV FITC

LDV FITC

Ref: TM-T23568

LDV FITC

Ref: 3D-HYB61007