CAS 120972-53-4

sarafotoxin S6B

Description:

Sarafotoxin S6B is a potent neurotoxin derived from the venom of the African snake, the mamba. It belongs to a class of peptides known as sarafotoxins, which are structurally related to endothelins and exhibit significant biological activity. Sarafotoxin S6B primarily acts as a vasoconstrictor, influencing blood vessel contraction and potentially leading to increased blood pressure. Its mechanism of action involves the binding to endothelin receptors, particularly the ET_A subtype, which plays a crucial role in cardiovascular regulation. The substance is characterized by its high affinity for these receptors, making it a valuable tool for studying receptor interactions and signaling pathways. Additionally, sarafotoxin S6B has been investigated for its potential implications in pharmacology and toxicology, particularly in understanding the effects of snake venom components on human physiology. Due to its potent biological effects, it is essential to handle this substance with caution in laboratory settings.

Formula: C₁₁₀H₁₅₉N₂₇O₃₄S₅

InChI: InChI=1/C110H162N26O35S5/c1-9-55(6)88(108(168)134-87(54(4)5)107(167)129-77(110(170)171)40-59-45-115-64-22-14-13-21-62(59)64)135-102(162)76(44-86(148)149)127-93(153)67(29-31-82(140)141)120-99(159)73(41-60-46-114-52-116-60)125-106(166)81(51-175)132-98(158)71(38-57-19-11-10-12-20-57)124-97(157)72(39-58-25-27-61(139)28-26-58)123-96(156)70(37-53(2)3)122-105(165)80(50-174)131-94(154)68(30-32-83(142)143)119-91(151)65(23-15-17-34-111)117-101(161)75(43-85(146)147)128-109(169)89(56(7)138)136-95(155)69(33-36-176-8)121-100(160)74(42-84(144)145)126-92(152)66(24-16-18-35-112)118-104(164)79(49-173)133-103(163)78(47-137)130-90(150)63(113)48-172/h10-14,19-22,25-28,45-46,52-56,63,65-81,87-89,115,137-139,172-175H,9,15-18,23-24,29-44,47-51,111-113H2,1-8H3,(H,114,116)(H,117,161)(H,118,164)(H,119,151)(H,120,159)(H,121,160)(H,122,165)(H,123,156)(H,124,157)(H,125,166)(H,126,152)(H,127,153)(H,128,169)(H,129,167)(H,130,150)(H,131,154)(H,132,158)(H,133,163)(H,134,168)(H,135,162)(H,136,155)(H,140,141)(H,142,143)(H,144,145)(H,146,147)(H,148,149)(H,170,171)/t55-,56+,63-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,87-,88-,89-/m0/s1

Synonyms:

• Sarafotoxin S6b, Atractaspsisengaddensis
• Csckdmtdkeclyfchqdviw
• Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp
• H-Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-Oh
• H-Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-Oh-Oh
• Sarafotoxin S6B (Atractaspis Engaddensis)
• Sarafotoxin S6B Atractaspis Engaddensis Sequence
• Sarafotoxin B

Sarafotoxin S6b

CAS: 120972-53-4

Sarafotoxin S6b, sourced from the venom of the Atractaspis engaddensis snake family, is one of four (S6a-d) isopeptides of the Sarafotoxins. This product is a synthetically produced toxin, containing disulfide bonds between Cys1-Cys15 and Cys3-Cys11.Due to their structural and functional homology to the endothelin peptides, Sarafotoxins can enhance vasoconstriction through stimulating the class A G-protein-coupled, endothelin ETA and ETB receptors. This in turn leads to left ventricular dysfunction and bronchoconstriction.
As the most potent Sarafotoxin, sarafotoxin S6b binds to both ETA and ETB receptors with a similar affinity to Endothelin-1. This is evident as when given to mice intravenously, sarafotoxin S6b caused cardiac arrest and death in mice almost immediately. Additional characteristics of S6b is its matrix metalloproteinase inhibitory activity due to it exhibiting a fold which is also found in the core region of tissue inhibitors of metalloproteinases (TIMPs).
Sarafotoxin S6b can be used as a pharmacological reagent to study the interactions of Endothelins and their corresponding receptors. This product is available as a 0.1mg vial.

Formula: C₁₁₀H₁₅₉N₂₇O₃₄S₅

Purity: Min. 95%

Molecular weight: 2,563.9 g/mol

Ref: 3D-PSF-4206-S

Sarafotoxin B trifluoroacetate salt

CAS: 120972-53-4

Component of snake venom; part of a family of vasoconstrictor isopeptides

Formula: C₁₁₀H₁₅₉N₂₇O₃₄S₅

Purity: Min. 95%

Molecular weight: 2,563.93 g/mol

Ref: 3D-FS110266