CAS 121009-77-6: simvastatin acid
Description:Simvastatin acid, identified by the CAS number 121009-77-6, is a pharmacologically active compound derived from simvastatin, which is a member of the statin class of drugs. It primarily functions as a lipid-lowering agent, inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol biosynthesis. The compound is characterized by its ability to reduce low-density lipoprotein (LDL) cholesterol levels in the bloodstream, thereby contributing to the prevention of cardiovascular diseases. Simvastatin acid is typically administered in its lactone form, which is converted to the active acid form in the body. It exhibits good oral bioavailability and is metabolized primarily in the liver. The substance is known for its relatively low solubility in water, which can influence its absorption and bioavailability. Additionally, simvastatin acid may have various side effects, including muscle pain and liver enzyme alterations, necessitating monitoring during therapy. Overall, it is a vital therapeutic agent in managing dyslipidemia and reducing the risk of atherosclerotic cardiovascular events.
Formula:C25H40O6
InChI:InChI=1/C25H40O6/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29)/t15-,16-,18+,19+,20-,21-,23-/m0/s1
- Synonyms:
- Tenivastatin [INN]
- L-654969
- Simvastatin hydroxy acid
- Tenivastatin
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta,8aalpha))-
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-, (betaR,deltaR,1S,2S,6R,8S,8aR)-
- (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl}-3,5-dihydroxyheptanoic acid
- Simvastatin acid
