CAS 121009-77-6

simvastatin acid

Description:

Simvastatin acid, identified by the CAS number 121009-77-6, is a pharmacologically active compound derived from simvastatin, which is a member of the statin class of drugs. It primarily functions as a lipid-lowering agent, inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol biosynthesis. The compound is characterized by its ability to reduce low-density lipoprotein (LDL) cholesterol levels in the bloodstream, thereby contributing to the prevention of cardiovascular diseases. Simvastatin acid is typically administered in its lactone form, which is converted to the active acid form in the body. It exhibits good oral bioavailability and is metabolized primarily in the liver. The substance is known for its relatively low solubility in water, which can influence its absorption and bioavailability. Additionally, simvastatin acid may have various side effects, including muscle pain and liver enzyme alterations, necessitating monitoring during therapy. Overall, it is a vital therapeutic agent in managing dyslipidemia and reducing the risk of atherosclerotic cardiovascular events.

Formula: C₂₅H₄₀O₆

InChI: InChI=1/C25H40O6/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29)/t15-,16-,18+,19+,20-,21-,23-/m0/s1

Synonyms:

• Tenivastatin [INN]
• L-654969
• Simvastatin hydroxy acid
• Tenivastatin
• 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta,8aalpha))-
• 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-, (betaR,deltaR,1S,2S,6R,8S,8aR)-
• (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl}-3,5-dihydroxyheptanoic acid
• Simvastatin acid

Tenivastatin

CAS: 121009-77-6

Tenivastatin

Purity: ≥98%

Molecular weight: 436.58g/mol

Ref: 54-BUP02232

Simvastatin EP Impurity A (Simvastatin Acid, Tenivastatin)

CAS: 121009-77-6

Formula: C₂₅H₄₀O₆

Molecular weight: 436.59

Ref: 4Z-S-1247

Tenivastatin

CAS: 121009-77-6

Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor used in the study of primary hyperlipidemia.

Formula: C₂₅H₄₀O₆

Purity: 99.56%

Color and Shape: Solid

Molecular weight: 436.58

Ref: TM-T24865

Simvastatin acid

CAS: 121009-77-6

Simvastatin acid is the active form of simvastatin, a drug used to lower blood cholesterol levels. Simvastatin acid inhibits HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate. This conversion is a rate-limiting step in the synthesis of cholesterol and other lipids. Simvastatin acid binds to polymerase chain and drug transporter proteins, which leads to cell lysis. The concentration–time curve for simvastatin acid is linear and the half-life is approximately 12 hours. When simvastatin acid is administered with drugs that are potent inducers of CYP3A4 or UGT1A1 enzymes, there may be an increased risk for drug interactions. Simvastatin acid has shown no significant human pharmacokinetic interactions with food or grapefruit juice at doses up to 200 mg/day. There are limited data on the pharmacokinetics of simvastatin

Formula: C₂₅H₄₀O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 436.58 g/mol

Ref: 3D-IS63828

Simvastatin Hydroxy Acid

CAS: 121009-77-6

Formula: C₂₅H₄₀O₆

Molecular weight: 436.59

Ref: ST-EA-CP-S4061