Big Endothelin-1 (human), with the CAS number 121014-53-7, is a precursor peptide that plays a crucial role in the regulation of vascular tone and blood pressure. It is derived from the larger precursor protein preproendothelin, which undergoes enzymatic cleavage to produce the active forms of endothelin. This peptide is characterized by its potent vasoconstrictive properties, influencing smooth muscle contraction and promoting the proliferation of vascular cells. Big Endothelin-1 is primarily produced by endothelial cells and has significant implications in various physiological and pathological processes, including cardiovascular function, renal function, and the pathophysiology of conditions such as hypertension and heart failure. Its biological activity is mediated through specific endothelin receptors, which are G protein-coupled receptors that trigger intracellular signaling pathways. Understanding the characteristics and functions of Big Endothelin-1 is essential for developing therapeutic strategies targeting endothelin-related disorders.

Big Endothelin-1 (human)

121014-53-7: Big Endothelin-1 (human), with the CAS number 121014-53-7, is a precursor peptide that plays a crucial role in the regulation of vascular tone and blood pressure. It is derived from the larger precursor protein preproendothelin, which undergoes enzymatic cleavage to produce the active forms of endothelin. This peptide is characterized by its potent vasoconstrictive properties, influencing smooth muscle contraction and promoting the proliferation of vascular cells. Big Endothelin-1 is primarily produced by endothelial cells and has significant implications in various physiological and pathological processes, including cardiovascular function, renal function, and the pathophysiology of conditions such as hypertension and heart failure. Its biological activity is mediated through specific endothelin receptors, which are G protein-coupled receptors that trigger intracellular signaling pathways. Understanding the characteristics and functions of Big Endothelin-1 is essential for developing therapeutic strategies targeting endothelin-related disorders.

Big endothelin-1 is a peptide that belongs to the class of endothelin family. It is used as a research tool in cell biology and pharmacology, because it binds to the ET-A receptor, which is a ligand-gated ion channel. Big endothelin-1 has been shown to activate this receptor, leading to an increase in intracellular calcium levels and vasoconstriction. It also inhibits the production of nitric oxide by endothelial cells and inhibits the activity of phospholipase A2. Big endothelin-1 has been shown to be an inhibitor of angiotensin converting enzyme (ACE).

CAS 121014-53-7

Big Endothelin-1 (human)

Big endothelin-1 (human)

Ref: 3D-WEA01453