CAS 121028-49-7

SECRETIN (RAT)

Description:

Secretin is a peptide hormone primarily produced in the S cells of the duodenum in response to acidic chyme entering the small intestine. The chemical substance known as "Secretin (Rat)" with the CAS number 121028-49-7 is a specific form of this hormone derived from rats. Secretin plays a crucial role in regulating the body's digestive processes, particularly by stimulating the pancreas to secrete bicarbonate-rich fluid, which helps neutralize stomach acid in the small intestine. Additionally, it promotes bile secretion from the liver and influences gastric motility. The structure of secretin consists of a chain of amino acids, typically around 27 residues in length, and it exhibits a high degree of biological activity. Its effects are mediated through specific receptors, leading to various physiological responses. Secretin is also involved in maintaining fluid and electrolyte balance in the gastrointestinal tract. Due to its significant role in digestion, secretin is of interest in both physiological studies and potential therapeutic applications.

Formula: C₁₂₉H₂₁₆N₄₂O₄₂

Synonyms:

• Hsdgtftselsrlqdsarlqrllqglv-Nh2
• His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Gln-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-Nh2 Rat
• H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Gln-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-Nh2
• Secretin (swine), 14-L-glutamine-
• HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-GLN-ASP-SER-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH2
• Secretin (33-59), rat
• Rat secretin-27
• SECRETIN (RAT)

Secretin (rat)

CAS: 121028-49-7

Bachem ID: 4037181.

Formula: C₁₂₉H₂₁₆N₄₂O₄₂

Purity: > 98%

Molecular weight: 3027.39

Ref: 01-4037181

Secretin (33-59), rat

CAS: 121028-49-7

Secretin (33-59), rat (Secretin (rat)) is a classical hormone in the gastrointestinal system and a neuropeptide.

Formula: C₁₂₉H₂₁₆N₄₂O₄₂

Purity: 98.12%

Color and Shape: Solid

Molecular weight: 3027.35

Ref: TM-TP1039

Secretin (rat)

CAS: 121028-49-7

Secretin is a gastrointestinal hormone secreted by S cells in the small intestine, targeting G-protein coupled secretin receptors in numerous cell types. Secretin is synthesised from the preprohormone pro-secretin and is involved in regulating gastric acid and bicarbonate ion secretion in the duodenum and regulating water homeostasis. During glucose intake, secretin stimulates the pancreas to release insulin.Secretin has clinical relevance as a method to detect gastrin-producing tumours. Administration of exogenous secretin to the duodenum for secretin stimulation test to occur. Secretin can also be used to detect pancreatic insufficiencies via s administration during endoscopic retrograde cholangiopancreatography (ERCP). This allows the detection of inflammatory and neoplastic conditions of the pancreas.Secretin plays a different role in the central nervous system, such that in secretin deficient mice, synaptic plasticity and hippocampal synaptic activity are altered. Thus, secretin can be categorised as a neuropeptide.

Formula: C₁₂₉H₂₁₆N₄₂O₄₂

Molecular weight: 3,027.36 g/mol

Ref: 3D-CRB1000722