Description:N(2),3-ethenodeoxyguanosine is a modified nucleoside that is derived from deoxyguanosine, featuring an etheno group at the N(2) position and a double bond at the 3-position of the sugar moiety. This compound is of particular interest in the field of molecular biology and genetics due to its role as a DNA adduct, which can result from exposure to certain environmental carcinogens. The presence of the etheno modification can lead to mispairing during DNA replication, potentially resulting in mutations. N(2),3-ethenodeoxyguanosine is often studied in the context of its effects on DNA stability and integrity, as well as its implications in cancer research. Its chemical structure includes a purine base linked to a deoxyribose sugar, and it is soluble in polar solvents. The compound is typically analyzed using techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry to assess its formation and repair mechanisms in biological systems. Understanding its characteristics is crucial for elucidating the molecular mechanisms underlying DNA damage and repair.
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