CAS 1210608-43-7

N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

Description:

N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide is a complex organic compound characterized by its unique structural features, including a pyridine ring and a picolinamide moiety. This substance exhibits a chiral center, contributing to its stereochemistry, which can influence its biological activity and interactions. The presence of fluorine atoms in the difluorophenyl group enhances its lipophilicity and may improve its binding affinity to biological targets. The compound's amine group is likely to participate in hydrogen bonding, which can be crucial for its solubility and reactivity. Additionally, the cyclohexyl group provides a hydrophobic character, potentially affecting the compound's pharmacokinetics. Overall, this compound may be of interest in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways, owing to its intricate structure and potential for selective activity. Further studies would be necessary to elucidate its specific properties and applications in various fields.

Formula: C₂₄H₂₃F₃N₄O

Synonyms:

• 2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-
• PIM447 (LGH447)
• N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
• EOS-60671
• PIM447 (LGH447) Free Base
• PIM447

PIM447

CAS: 1210608-43-7

PIM447

Purity: ≥98%

Molecular weight: 440.46g/mol

Ref: 54-BUP17522

PIM447

CAS: 1210608-43-7

Formula: C₂₄H₂₃F₃N₄O

Molecular weight: 440.47

Ref: 4Z-P-225001

PIM 447

Controlled Product

CAS: 1210608-43-7

Formula: C₂₄H₂₃F₃N₄O

Color and Shape: Neat

Molecular weight: 440.461

Ref: TR-P446750

PIM 447

CAS: 1210608-43-7

PIM 447 is a tyrosine kinase inhibitor that inhibits the activity of JAK2. This drug has been shown to inhibit the growth of prostate cancer cells in tissue culture and may be useful for the treatment of t-cell lymphomas. PIM 447 binds to a region on the JAK2 protein that is required for its function and prevents it from phosphorylating tyrosine residues. It also inhibits the transcriptional activity of JAK2, which may lead to inhibition of cell proliferation and anti-tumour effects. Monoclonal antibodies against PIM 447 have been developed for use as a therapy for B-cell malignancies.

Formula: C₂₄H₂₃F₃N₄O

Purity: Min. 95%

Molecular weight: 440.46 g/mol

Ref: 3D-KYB60843

PIM447

CAS: 1210608-43-7

PIM447 (LGH447) is a pan-PIM kinase inhibitor with anti-tumor and bone protective effects. PIM447 reduces the viability, and motility of HuH6 cell.

Formula: C₂₄H₂₃F₃N₄O

Purity: 98.97%

Color and Shape: Solid

Molecular weight: 440.46

Ref: TM-T12475