CAS 121080-63-5

SN-38 GLUCURONIDE

Description:

SN-38 glucuronide is a chemical compound that serves as a metabolite of SN-38, the active form of the chemotherapeutic agent irinotecan. It is characterized by the presence of a glucuronic acid moiety, which is conjugated to the SN-38 structure, enhancing its solubility and facilitating excretion. This compound is primarily formed in the liver through the process of glucuronidation, a phase II metabolic reaction that detoxifies and increases the water solubility of lipophilic drugs. SN-38 glucuronide is generally considered to be less pharmacologically active than its parent compound, SN-38, but it plays a crucial role in the pharmacokinetics of irinotecan therapy. The compound is of interest in pharmacology and toxicology, particularly in understanding the metabolism and elimination pathways of irinotecan, as well as its potential impact on therapeutic efficacy and safety profiles in cancer treatment. Its CAS number, 121080-63-5, is used for identification in chemical databases and regulatory contexts.

Formula: C₂₈H₂₈N₂O₁₁

InChI: InChI=1/C28H28N2O11/c1-3-12-13-7-11(40-26-22(33)20(31)21(32)23(41-26)25(35)36)5-6-17(13)29-19-14(12)9-30-18(19)8-16-15(24(30)34)10-39-27(37)28(16,38)4-2/h5-8,20-23,26,31-33,38H,3-4,9-10H2,1-2H3,(H,35,36)/t20-,21-,22-,23?,26-,28-/m0/s1

SMILES: CCc1c2cc(ccc2nc2c1Cn1c2cc2c(COC(=O)[C@@]2(CC)O)c1=O)O[C@@H]1[C@H]([C@H]([C@@H](C(C(=O)O)O1)O)O)O

SN-38-d5 Glucuronide

CAS: 121080-63-5

Formula: C₂₈H₂₃D₅N₂O₁₁

Molecular weight: 573.57

Ref: 4Z-I-1822

SN-38 glucuronide

CAS: 121080-63-5

Formula: C₂₈H₂₈N₂O₁₁

Purity: ≥ 98.0%

Color and Shape: Off-white to pale yellow solid

Molecular weight: 568.53

Ref: 7W-GC8306

(2S,3S,4S,5R,6S)-6-(((S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

CAS: 121080-63-5

(2S,3S,4S,5R,6S)-6-(((S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

Purity: 98%

Molecular weight: 568.54g/mol

Ref: 54-OR1062985

SN-38 Glucuronide

CAS: 121080-63-5

Formula: C₂₈H₂₈N₂O₁₁

Color and Shape: Yellow Solid

Molecular weight: 568.54

Ref: 4Z-I-185

SN-38 glucuronide

CAS: 121080-63-5

SN-38 glucuronide, inactive product of Irinotecan, aids in colon/rectal cancer research as a topoisomerase I inhibitor.

Formula: C₂₈H₂₈N₂O₁₁

Color and Shape: Solid

Molecular weight: 568.53

Ref: TM-T73905

SN-38-d3 Glucuronide

Controlled Product

CAS: 121080-63-5

Applications A labelled metabolite of Irinotecan
References Fujita, K., et al.: Biol. Pharm. Bull., 31, 2137 (2008), Sandanaraj, E., et al.: Pharmacogen. J., 8, 174 (2008), Chen, K., et al.: Chem. Biol., 15, 1277 (2008), Prijovich, Z., et al.: Mol. Canc. Ther., 8, 940 (2009),

Formula: C₂₈H₂₅D₃N₂O₁₁

Color and Shape: Neat

Molecular weight: 571.55

Ref: TR-S589982

SN-38 Glucuronide

CAS: 121080-63-5

Applications A metabolite of Irinotecan
References Fujita, K., et al.: Biol. Pharm. Bull., 31, 2137 (2008), Sandanaraj, E., et al.: Pharmacogen. J., 8, 174 (2008), Chen, K., et al.: Chem. Biol., 15, 1277 (2008), Prijovich, Z., et al.: Mol. Canc. Ther., 8, 940 (2009),

Formula: C₂₈H₂₈N₂O₁₁

Color and Shape: White To Yellow

Molecular weight: 568.53

Ref: TR-S589980

SN-38 Glucuronide-d5

Controlled Product

CAS: 121080-63-5

Formula: C₂₈D₅H₂₃N₂O₁₁

Color and Shape: Neat

Molecular weight: 573.559

Ref: TR-S589984

Irinotecan Impurity 4

CAS: 121080-63-5

Formula: C₂₈H₂₈N₂O₁₁

Molecular weight: 568.54

Ref: ST-EA-CP-I9024

SN-38 glucuronide

CAS: 121080-63-5

SN-38 glucuronide is a metabolite of irinotecan that inhibits the growth of cancer cells by binding to the DNA polymerase, blocking the synthesis of DNA. SN-38 glucuronide has potent antitumor activity and high values for inhibiting tumor metastasis. It is mainly excreted in urine as a conjugate with glucuronic acid, which may be why urine samples are often used to measure its concentration. SN-38 glucuronide also interacts with other drugs, including chemical inhibitors and ATP-binding cassette transporters, which can affect its pharmacological properties.

Formula: C₂₈H₂₈N₂O₁₁

Purity: Min. 97.5 Area-%

Color and Shape: Powder

Molecular weight: 568.53 g/mol

Ref: 3D-MS16856