CAS 121080-63-5
:SN-38 GLUCURONIDE
Description:
SN-38 glucuronide is a chemical compound that serves as a metabolite of SN-38, the active form of the chemotherapeutic agent irinotecan. It is characterized by the presence of a glucuronic acid moiety, which is conjugated to the SN-38 structure, enhancing its solubility and facilitating excretion. This compound is primarily formed in the liver through the process of glucuronidation, a phase II metabolic reaction that detoxifies and increases the water solubility of lipophilic drugs. SN-38 glucuronide is generally considered to be less pharmacologically active than its parent compound, SN-38, but it plays a crucial role in the pharmacokinetics of irinotecan therapy. The compound is of interest in pharmacology and toxicology, particularly in understanding the metabolism and elimination pathways of irinotecan, as well as its potential impact on therapeutic efficacy and safety profiles in cancer treatment. Its CAS number, 121080-63-5, is used for identification in chemical databases and regulatory contexts.
Formula:C28H28N2O11
InChI:InChI=1/C28H28N2O11/c1-3-12-13-7-11(40-26-22(33)20(31)21(32)23(41-26)25(35)36)5-6-17(13)29-19-14(12)9-30-18(19)8-16-15(24(30)34)10-39-27(37)28(16,38)4-2/h5-8,20-23,26,31-33,38H,3-4,9-10H2,1-2H3,(H,35,36)/t20-,21-,22-,23?,26-,28-/m0/s1
SMILES:CCc1c2cc(ccc2nc2c1Cn1c2cc2c(COC(=O)[C@@]2(CC)O)c1=O)O[C@@H]1[C@H]([C@H]([C@@H](C(C(=O)O)O1)O)O)O
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Found 10 products.
SN-38 glucuronide
CAS:Formula:C28H28N2O11Purity:≥ 98.0%Color and Shape:Off-white to pale yellow solidMolecular weight:568.53(2S,3S,4S,5R,6S)-6-(((S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
CAS:(2S,3S,4S,5R,6S)-6-(((S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acidPurity:98%Molecular weight:568.54g/molSN-38 glucuronide
CAS:<p>SN-38 glucuronide, inactive product of Irinotecan, aids in colon/rectal cancer research as a topoisomerase I inhibitor.</p>Formula:C28H28N2O11Color and Shape:SolidMolecular weight:568.53SN-38-d3 Glucuronide
CAS:Controlled Product<p>Applications A labelled metabolite of Irinotecan<br>References Fujita, K., et al.: Biol. Pharm. Bull., 31, 2137 (2008), Sandanaraj, E., et al.: Pharmacogen. J., 8, 174 (2008), Chen, K., et al.: Chem. Biol., 15, 1277 (2008), Prijovich, Z., et al.: Mol. Canc. Ther., 8, 940 (2009),<br></p>Formula:C28H25D3N2O11Color and Shape:NeatMolecular weight:571.55SN-38 Glucuronide
CAS:<p>Applications A metabolite of Irinotecan<br>References Fujita, K., et al.: Biol. Pharm. Bull., 31, 2137 (2008), Sandanaraj, E., et al.: Pharmacogen. J., 8, 174 (2008), Chen, K., et al.: Chem. Biol., 15, 1277 (2008), Prijovich, Z., et al.: Mol. Canc. Ther., 8, 940 (2009),<br></p>Formula:C28H28N2O11Color and Shape:White To YellowMolecular weight:568.53SN-38 Glucuronide-d5
CAS:Controlled ProductFormula:C28D5H23N2O11Color and Shape:NeatMolecular weight:573.559SN-38 glucuronide
CAS:<p>SN-38 glucuronide is a metabolite of irinotecan that inhibits the growth of cancer cells by binding to the DNA polymerase, blocking the synthesis of DNA. SN-38 glucuronide has potent antitumor activity and high values for inhibiting tumor metastasis. It is mainly excreted in urine as a conjugate with glucuronic acid, which may be why urine samples are often used to measure its concentration. SN-38 glucuronide also interacts with other drugs, including chemical inhibitors and ATP-binding cassette transporters, which can affect its pharmacological properties.</p>Formula:C28H28N2O11Purity:Min. 97.5 Area-%Color and Shape:PowderMolecular weight:568.53 g/mol
