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CAS 1211443-80-9

:

LEE011 (hydrochloride)

Description:
LEE011 (hydrochloride), with the CAS number 1211443-80-9, is a small molecule inhibitor primarily known for its role in targeting cyclin-dependent kinases (CDKs), particularly CDK4 and CDK6. This compound is notable for its potential therapeutic applications in oncology, particularly in the treatment of various cancers, including breast cancer, where it may help to inhibit tumor growth by disrupting the cell cycle. LEE011 is typically characterized by its ability to induce cell cycle arrest in cancer cells, thereby preventing proliferation. As a hydrochloride salt, it is often more soluble in aqueous solutions, which can enhance its bioavailability. The compound is usually administered in a controlled dosage form, and its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for its efficacy and safety profile. Ongoing research continues to explore its effectiveness in combination therapies and its overall impact on cancer treatment regimens.
Formula:C23H31ClN8O
Synonyms:
  • LEE011 (hydrochloride)
  • RIBOCICLIB HYDROCHLORIDE (LEE011 HYDROCHLORIDE)
  • LEE011 HCl
  • 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide hydrochloride
  • Ribociclib HCl
  • RIBOCICLIB; LEE 011; LEE-011
  • 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride (1:1)
  • Ribociclib (Hydrochloride)
  • 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride
  • LEE-011 HCl salt, Ribociclib HCl salt
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