CAS 1211443-80-9

LEE011 (hydrochloride)

Description:

LEE011 (hydrochloride), with the CAS number 1211443-80-9, is a small molecule inhibitor primarily known for its role in targeting cyclin-dependent kinases (CDKs), particularly CDK4 and CDK6. This compound is notable for its potential therapeutic applications in oncology, particularly in the treatment of various cancers, including breast cancer, where it may help to inhibit tumor growth by disrupting the cell cycle. LEE011 is typically characterized by its ability to induce cell cycle arrest in cancer cells, thereby preventing proliferation. As a hydrochloride salt, it is often more soluble in aqueous solutions, which can enhance its bioavailability. The compound is usually administered in a controlled dosage form, and its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for its efficacy and safety profile. Ongoing research continues to explore its effectiveness in combination therapies and its overall impact on cancer treatment regimens.

Formula: C₂₃H₃₁ClN₈O

Synonyms:

• LEE011 (hydrochloride)
• RIBOCICLIB HYDROCHLORIDE (LEE011 HYDROCHLORIDE)
• LEE011 HCl
• 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide hydrochloride
• Ribociclib HCl
• RIBOCICLIB; LEE 011; LEE-011
• 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride (1:1)
• Ribociclib (Hydrochloride)
• 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride
• LEE-011 HCl salt, Ribociclib HCl salt

LEE011 (hydrochloride)

CAS: 1211443-80-9

Formula: C₂₃H₃₁ClN₈O

Purity: 98%

Color and Shape: Solid

Molecular weight: 470.9982

Ref: IN-DA008THC

7-Cyclopentyl-N,N-Dimethyl-2-((5-(Piperazin-1-Yl)Pyridin-2-Yl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide Hydrochloride

CAS: 1211443-80-9

7-Cyclopentyl-N,N-Dimethyl-2-((5-(Piperazin-1-Yl)Pyridin-2-Yl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide Hydrochloride

Purity: 98%

Molecular weight: 471g/mol

Ref: 54-OR1026609

Ribociclib hydrochloride

CAS: 1211443-80-9

Ribociclib hydrochloride (LEE011 HCl) is a selective, orally active cyclin-dependent kinase CDK4/6 inhibitor (IC50=10/39 nM) that inhibits proliferation.

Formula: C₂₃H₃₁ClN₈O

Purity: 99.87%

Color and Shape: Solid

Molecular weight: 471

Ref: TM-T15730

Ribociclib HCl

CAS: 1211443-80-9

Inhibitor of CDK4/6 serine/threonine kinases; antineoplastic

Formula: C₂₃H₃₀N₈O·HCl

Purity: Min. 95%

Color and Shape: White To Yellow Solid

Molecular weight: 471 g/mol

Ref: 3D-FR106415

Ribociclib hydrochloride

CAS: 1211443-80-9

Purity: 98%

Molecular weight: 471.01

Ref: 10-F979236

Ribociclib HCl

Controlled Product

CAS: 1211443-80-9

Formula: C₂₃H₃₀N₈OHCl

Color and Shape: Neat

Molecular weight: 471.0

Ref: TR-R215530