CAS 121181-53-1: Filgrastim

Description: Filgrastim is a recombinant form of human granulocyte colony-stimulating factor (G-CSF), primarily used to stimulate the production of neutrophils in patients undergoing chemotherapy or those with certain bone marrow disorders. It is a glycoprotein composed of 175 amino acids and has a molecular weight of approximately 18 kDa. Filgrastim functions by binding to specific receptors on hematopoietic progenitor cells in the bone marrow, promoting their proliferation and differentiation into neutrophils. This action helps to reduce the incidence of infections in patients with neutropenia. The substance is typically administered via subcutaneous injection and has a relatively short half-life, necessitating regular dosing. Filgrastim is generally well-tolerated, though potential side effects may include bone pain, splenic rupture, and allergic reactions. Its use is contraindicated in patients with a history of hypersensitivity to filgrastim or any component of the formulation. Overall, filgrastim plays a crucial role in supportive care for patients with compromised immune systems.

Formula: C₈₄₅H₁₃₃₉N₂₂₃O₂₄₃S₉

Synonyms:

• Filgrastim [USAN:INN:BAN]
• Biograstim
• Drg-0086
• Filgrastim Hexal
• Filgrastim ratiopharm
• Filgrastime
• Filgrastime [INN-French]
• Filgrastimum
• Filgrastimum [INN-Latin]
• Granulocyte colony stimulating factor, recombinant
• N-L-Methionylcolony-stimulating factor (human clone 1034)
• Neupogen
• Ratiograstim
• Recombinant methionyl granulocyte colony stimulating factor
• Tevagrastim
• Unii-Pvi5M0M1Gw
• Zarzio
• r-metHug-C-SF
• r-metHug-CSF
• rG-CSF
• Colony-stimulating factor (human clone 1034), N-L-methionyl-
• Filgrastim

Filgrastim for Bioassay

CAS: 121181-53-1

Immunological products, unmixed, not put up in measured doses or in forms or packings for …

• Formula: C₈₄₅H₁₃₃₉N₂₂₃O₂₄₃S₉
• Color and Shape: White Solid Lyophilized Cake Pellets
• Molecular weight: 18786.67611

Filgrastim System Suitability

CAS: 121181-53-1

Immunological products, mixed, not put up in measured doses or in forms or packings for …

• Formula: C₈₄₅H₁₃₃₉N₂₂₃O₂₄₃S₉
• Color and Shape: White Powder
• Molecular weight: 18786.67611

Filgrastim

CAS: 121181-53-1

• Formula: C₈₄₅H₁₃₄₃N₂₂₃O₂₄₃S₉
• Molecular weight: 18802.8

Filgrastim RS

CAS: 121181-53-167-68-5

• Color and Shape: Colorless Liquid Clear Liquid

Filgrastim

CAS: 121181-53-1

Filgrastim is a recombinant protein that acts as a colony-stimulating factor. It promotes the growth …

• Formula: C₈₄₅H₁₃₃₉N₂₂₃O₂₄₃S₉
• Purity: Min. 95%
• Molecular weight: 18,798.62 g/mol