CAS 1211866-85-1

TC-N 1752

CAS: 1211866-85-1

TC-N 1752

Purity: ≥95%

Molecular weight: 516.52g/mol

Ref: 54-BUP07717

Nav1.7 blocker 52

CAS: 1211866-85-1

Nav1.7 is a voltage-gated ion channel that is important for the transmission of pain signals. Nav1.7 blockers are designed to inhibit Nav1.7 with an IC50 value of ~0.4 μM, and can be used in the treatment of chronic pain associated with inflammatory conditions, such as arthritis and fibromyalgia, or cancer-related pain. These drugs have been shown to inhibit the activity of Nav1.7 by binding to residues in its activation gate, preventing the opening of sodium channels at resting membrane potentials and blocking the propagation of action potentials in peripheral sensory neurons, thereby inhibiting nociceptive neurotransmission.

Formula: C₂₅H₂₇F₃N₆O₃

Purity: Min. 95%

Molecular weight: 516.52 g/mol

Ref: 3D-LYB86685

TC-N 1752

CAS: 1211866-85-1

TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.

Formula: C₂₅H₂₇F₃N₆O₃

Purity: 99.71%

Color and Shape: Solid

Molecular weight: 516.52

Ref: TM-T23439