CAS 121264-06-0

pacidamycin 2

Description:

Pacidamycin 2, with the CAS number 121264-06-0, is a naturally occurring antibiotic that belongs to the class of compounds known as aminoglycosides. It is primarily derived from the fermentation of specific strains of bacteria, particularly those in the genus Micromonospora. This compound exhibits potent antibacterial activity, particularly against Gram-positive bacteria, making it of interest in the development of new antimicrobial therapies. Pacidamycin 2 functions by inhibiting protein synthesis, which is crucial for bacterial growth and reproduction. Its structure features a complex arrangement of amino sugars and cyclic components, contributing to its biological activity. The compound has been studied for its potential applications in treating infections, especially in the context of antibiotic resistance. However, like many antibiotics, its use may be limited by factors such as toxicity, resistance development, and the need for further clinical evaluation. Overall, pacidamycin 2 represents a significant area of research in the search for effective antibacterial agents.

Formula: C₃₉H₄₉N₉O₁₂

InChI: InChI=1/C39H49N9O12/c1-20(40)29(50)18-28(46(3)34(54)26(43-33(53)21(2)41)16-23-10-7-11-24(49)14-23)32(42)35(55)48(38(58)44-27(37(56)57)15-22-8-5-4-6-9-22)19-25-17-30(51)36(60-25)47-13-12-31(52)45-39(47)59/h4-14,19-21,26-28,30,32,36,49,51H,15-18,40-42H2,1-3H3,(H,43,53)(H,44,58)(H,56,57)(H,45,52,59)/b25-19+/t20-,21-,26-,27?,28?,30?,32?,36?/m0/s1

Synonyms:

• pacidamycin 2
• Butanamide, N-(((1-carboxy-2-phenylethyl)amino)carbonyl)alanyl-N3-(N-alanyl-3-hydroxyphenylalanyl)-N-((5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)dihydro-4-hydroxy-2(3H)-furanylidene)methyl)-N3-methyl-2,3-diamino-
• N-(((1-Carboxy-2-phenylethyl)amino)carbonyl)alanyl-N3-(N-alanyl-3-hydroxyphenylalanyl)-N-((5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)dihydro-4-hydroxy-2(3H)-furanylidene)methyl)-N3-methyl-2,3-diaminobutanamide
• L-alanyl-N-{(4S)-4-amino-1-[1-amino-2-([(1-carboxy-2-phenylethyl)carbamoyl]{(E)-[5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxydihydrofuran-2(3H)-ylidene]methyl}amino)-2-oxoethyl]-3-oxopentyl}-3-hydroxy-N-methyl-L-phenylalaninamide

Pacidamycin 2

CAS: 121264-06-0

Pacidamycin 2 exhibits inhibitory effects against Pseudomonas aeruginosa. It also affects a limited number of other bacterial strains, including Staphylococcus aureus and Escherichia coli.

Formula: C₃₉H₄₉N₉O₁₂

Color and Shape: Solid

Molecular weight: 835.859

Ref: TM-TN10566