CAS 1214265-57-2

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide

Description:

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide, with the CAS number 1214265-57-2, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple functional groups such as amides, thioethers, and aromatic rings. This compound is notable for its potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways. The presence of a piperazine moiety suggests possible interactions with biological receptors, enhancing its pharmacological profile. Additionally, the chloro and pyrimidine groups may contribute to its reactivity and solubility properties. As with many compounds in this class, its stability, solubility, and bioactivity are influenced by the arrangement of its substituents, making it a subject of interest for further research in drug design and development. Safety and handling precautions should be observed, as with any chemical substance, particularly in laboratory settings.

Formula: C₂₄H₂₅ClN₆OS

InChI: InChI=1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)

InChI key: InChIKey=KIISCIGBPUVZBF-UHFFFAOYSA-N

SMILES: S(C1=NC(NC2=CC=C(C=C2)N3CCN(C)CC3)=NC=C1Cl)C4=CC(NC(C=C)=O)=CC=C4

Synonyms:

• 2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-
• N-[3-[5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide
• N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide
• Wz-8040
• Wz8040

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide

CAS: 1214265-57-2

Formula: C₂₄H₂₅ClN₆OS

Purity: 98%

Molecular weight: 481.0129

Ref: IN-DA009CFP

WZ8040

CAS: 1214265-57-2

WZ8040

Purity: ≥95%

Molecular weight: 481.01g/mol

Ref: 54-BUP02504

WZ8040

CAS: 1214265-57-2

WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).

Formula: C₂₄H₂₅ClN₆OS

Purity: 97.42% - 99.785%

Color and Shape: Solid

Molecular weight: 481.01

Ref: TM-T6734

WZ8040

CAS: 1214265-57-2

WZ8040 is a factor receptor inhibitor that blocks the epidermal growth factor receptor (EGFR) family of tyrosine kinase receptors. It is an inhibitor of the EGFR family of tyrosine kinases and has been shown to inhibit proliferation in vitro and in vivo. WZ8040 also inhibits the activation of downstream signaling pathways, including ERK, AKT, and STAT3, which regulate cell survival and proliferation. This drug has been shown to be effective against bladder cancer cells with wild-type EGFR but not those that are resistant to quinazoline-based drugs such as PD168393 or pelitinib.

Formula: C₂₄H₂₅ClN₆OS

Purity: Min. 95%

Molecular weight: 481.01 g/mol

Ref: 3D-PYB26557