CAS 1214726-89-2

AS 2521780

CAS: 1214726-89-2

AS 2521780 is a potent and selective inhibitor of the enzyme tyrosine phosphatase-1B (PTP-1B) that is used to treat autoimmune diseases. PTP-1B inhibitors are used as immunosuppressants in patients undergoing renal transplantation or other types of organ transplants, or for the treatment of cardiac diseases. AS 2521780 has been shown to inhibit the proliferation of T cells and CD4+CD25+Foxp3+ regulatory T cells. This drug also inhibits the proliferation of mononuclear cells, which are found in blood, and reduces the production of cytokines by these cells. The inhibition of PTP-1B may be involved in many aspects of cell function, including insulin secretion from pancreatic beta cells, glucose metabolism in muscle cells, and cardiac contractility. AS 2521780 is a potential drug target for diabetes mellitus type 2 and heart failure.

Formula: C₃₀H₄₁N₇OS

Purity: Min. 95%

Molecular weight: 547.8 g/mol

Ref: 3D-PYB72689

AS2521780

CAS: 1214726-89-2

AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).

Formula: C₃₀H₄₁N₇OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 547.76

Ref: TM-T14328