CAS 1215797-41-3

N,N-Dideethylchloroquine-d4

Description:

N,N-Dideethylchloroquine-d4 is a deuterated derivative of chloroquine, a well-known antimalarial drug. This compound is characterized by the presence of two ethyl groups that have been removed from the nitrogen atoms in the chloroquine structure, along with the incorporation of deuterium, a stable isotope of hydrogen, which replaces certain hydrogen atoms in the molecule. The deuteration enhances the compound's stability and can improve its detection in analytical studies, such as mass spectrometry. N,N-Dideethylchloroquine-d4 is primarily used in research settings, particularly in pharmacokinetic studies to trace the metabolism and distribution of chloroquine in biological systems. Its molecular structure contributes to its unique properties, including altered solubility and potential differences in biological activity compared to its non-deuterated counterpart. As with many deuterated compounds, it is important for researchers to handle it with care, following appropriate safety protocols, as it may still exhibit biological activity.

Formula: C₁₄H₁₈ClN₃

Synonyms:

• [2H4]-Didesethyl Chloroquine
• Didesethyl Chloroquine-d4
• N4-(7-Chloro-4-quinolinyl)-1,4-pentanediamine-d4
• Bisdesethylchloroquine-d4
• 4-[(4-Amino-1-methylbutyl)amino]-7-chloroquinoline-d4
• Bisdeethylchloroquine-d4
• N,N-Dideethylchloroquine-d4

Didesethyl Chloroquine-d4

CAS: 1215797-41-3

Formula: C₁₄H₁₄D₄ClN₃

Color and Shape: White To Off-White Solid

Molecular weight: 267.79

Ref: 4Z-C-926

Didesethyl Chloroquine-d4

Controlled Product

CAS: 1215797-41-3

Applications A labelled metabolite of Chloroquine. It is a COVID19-related research product.
References Ohkuma, S., et al.: J. Cell. Biol., 90, 656 (1981), Araki, N., et al.: J. Biol. Chem., 267, 10211 (1992), Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003), Traebert, M., et al.: Eur. J. Pharmacol., 484, 41 (2004),

Formula: C₁₄H₁₄D₄ClN₃

Color and Shape: Neat

Molecular weight: 267.79

Ref: TR-D440962