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Valspodar

CAS 121584-18-7: Valspodar

Description:Valspodar, also known by its chemical name PSC 833, is a potent inhibitor of the P-glycoprotein (P-gp) efflux pump, which plays a significant role in multidrug resistance in cancer therapy. It is classified as a non-cytotoxic compound and is primarily used in research settings to enhance the efficacy of various anticancer drugs by preventing their expulsion from cancer cells. Valspodar exhibits a complex structure that includes multiple aromatic rings, contributing to its lipophilicity and ability to cross cellular membranes. The compound has been studied for its potential to improve the pharmacokinetics of chemotherapeutic agents, thereby increasing their intracellular concentrations and therapeutic effectiveness. Additionally, Valspodar has been evaluated in clinical trials, particularly in combination with other drugs, to assess its ability to overcome resistance mechanisms in tumors. Its safety profile and interactions with other medications are important considerations in its application in cancer treatment. Overall, Valspodar represents a significant area of interest in the ongoing efforts to combat drug resistance in oncology.

Formula:C63H111N11O12

InChI:InChI=1/C63H111N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-52H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46+,47+,49+,50+,51+,52+/m1/s1

  • Synonyms:
  • Valspodar [USAN:INN]
  • Sdz psc 833
  • 3'-Keto-bmt(1)-val(2)-cyclosporin A
  • Cyclo(((2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl)-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl)
  • Cyclosporin D, 6-((2S,4R,6E)-4-methyl-2-methylamino)-3-oxo-6-octenoic acid)-
  • Psc 833
  • Unii-Q7Zp55Kf3X
  • Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25,28-nonamethyl-3,21,30-tris(1-methylethyl)-33-[(2R,4E)-2-methylhex-4-enoyl]-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
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Cyclosporin A, 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-

CAS:121584-18-7

Ref: IN-DA0015BN

1mg190.00 €
5mgTo inquire
Estimated delivery in United States, on Friday 7 Mar 2025
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Valspodar

CAS:121584-18-7

Ref: TM-T17216

1mg274.00 €
5mg882.00 €
10mg1,415.00 €
25mgTo inquire
Estimated delivery in United States, on Monday 10 Mar 2025
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Ref: 4Z-V-067001

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Friday 14 Mar 2025
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Valspodar

Controlled Product
CAS:121584-18-7

Ref: TR-V096100

1mg256.00 €
5mg1,117.00 €
10mg1,776.00 €
Estimated delivery in United States, on Thursday 17 Apr 2025
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Valspodar

CAS:121584-18-7

Ref: 3D-FV28665

1kg757.00 €
2kg1,152.00 €
250g304.00 €
500g475.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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