CAS 121584-18-7

Valspodar

Description:

Valspodar, also known by its chemical name PSC 833, is a potent inhibitor of the P-glycoprotein (P-gp) efflux pump, which plays a significant role in multidrug resistance in cancer therapy. It is classified as a non-cytotoxic compound and is primarily used in research settings to enhance the efficacy of various anticancer drugs by preventing their expulsion from cancer cells. Valspodar exhibits a complex structure that includes multiple aromatic rings, contributing to its lipophilicity and ability to cross cellular membranes. The compound has been studied for its potential to improve the pharmacokinetics of chemotherapeutic agents, thereby increasing their intracellular concentrations and therapeutic effectiveness. Additionally, Valspodar has been evaluated in clinical trials, particularly in combination with other drugs, to assess its ability to overcome resistance mechanisms in tumors. Its safety profile and interactions with other medications are important considerations in its application in cancer treatment. Overall, Valspodar represents a significant area of interest in the ongoing efforts to combat drug resistance in oncology.

Formula: C₆₃H₁₁₁N₁₁O₁₂

InChI: InChI=1/C63H111N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-52H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46+,47+,49+,50+,51+,52+/m1/s1

Synonyms:

• Valspodar [USAN:INN]
• Sdz psc 833
• 3'-Keto-bmt(1)-val(2)-cyclosporin A
• Cyclo(((2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl)-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl)
• Cyclosporin D, 6-((2S,4R,6E)-4-methyl-2-methylamino)-3-oxo-6-octenoic acid)-
• Psc 833
• Unii-Q7Zp55Kf3X
• Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25,28-nonamethyl-3,21,30-tris(1-methylethyl)-33-[(2R,4E)-2-methylhex-4-enoyl]-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

Cyclosporin A, 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-

CAS: 121584-18-7

Formula: C₆₃H₁₁₁N₁₁O₁₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 1214.6219

Ref: IN-DA0015BN

Valspodar

CAS: 121584-18-7

Valspodar

Purity: ≥95%

Molecular weight: 1214.62g/mol

Ref: 54-BUP16309

Valspodar

CAS: 121584-18-7

Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.

Formula: C₆₃H₁₁₁N₁₁O₁₂

Purity: 95% - >99.99%

Color and Shape: Solid

Molecular weight: 1214.62

Ref: TM-T17216

Valspodar

CAS: 121584-18-7

Formula: C₆₃H₁₁₁N₁₁O₁₂

Molecular weight: 1214.65

Ref: 4Z-V-067001

Valspodar

Controlled Product

CAS: 121584-18-7

Applications Antineoplastic adjunct (chemosensitizer).
References Boesch, D., et al.: exp. Cell Res., 196, 26 (1991), Lush, R.M., et al.: J. Clin. Pharmacol., 37, 123 (1997), Scott, M.G., et al.: Clin. Chem., 43, 505 (1997), Advani, R., et al.: Blood, 93, 787 (1999),

Formula: C₆₃H₁₁₁N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1214.62

Ref: TR-V096100

Valspodar

CAS: 121584-18-7

P-glycoprotein (MDR1) inhibitor; non-immunosuppressive cyclosporin A analog

Formula: C₆₃H₁₁₁N₁₁O₁₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 1,214.62 g/mol

Ref: 3D-FV28665