CAS 1216420-11-9

OSI-420-d4, Free Base (Desmethyl Erlotinib-d4)

Description:

OSI-420-d4, also known as Desmethyl Erlotinib-d4, is a deuterated analog of Erlotinib, which is a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is characterized by the presence of deuterium atoms, which are isotopes of hydrogen, replacing specific hydrogen atoms in the molecular structure. This modification enhances the stability and tracking of the compound in various biochemical studies. OSI-420-d4 is primarily utilized in pharmacokinetic studies and research involving drug metabolism, as the deuterated form can provide insights into the metabolic pathways and the pharmacological behavior of the parent compound, Erlotinib. The compound is typically a white to off-white solid and is soluble in organic solvents. Its molecular structure includes a quinazoline core, which is essential for its activity against EGFR. As with many pharmaceutical compounds, handling OSI-420-d4 requires adherence to safety protocols to mitigate any potential risks associated with its use in research settings.

Formula: C₂₁H₂₁N₃O₄

Synonyms:

• OSI-420-d4, Free Base (Desmethyl Erlotiniβ-d4)
• 2-[7-(2-methoxyethoxy)-4-(2,3,4,6-tetradeuterio-5-ethynylanilino)quinazolin-6-yl]oxyethanol
• OSI-420-d4
• [2H4]-O-Desmethylerlotinib
• 2-[[4-[(3-Ethynylphenyl-d4)aMino]-7-(2-Methoxyethoxy)-6-quinazolinyl]oxy]ethanol
• Erlotinib Impurity 118
• OSI-420-d4, Free Base (Desmethyl Erlotinib-d4)
• O-Desmethylerlotinib

Erlotinib O-Desmethyl Metabolite Isomer (M-14)-d4 HCl (Phenyl-ring-d4)

CAS: 1216420-11-9

Formula: C₂₁H₁₇D₄N₃O₄·HCl

Color and Shape: Pale Yellow Solid

Molecular weight: 383.44 36.46

Ref: 4Z-E-28116

OSI-420-d4, Free Base (Desmethyl Erlotinib-d4)

Controlled Product

CAS: 1216420-11-9

Applications A labelled metabolite of Erlotinib (E625000), an anti cancer agent.
References Rusch, V., et al.: Cancer Res., 53, 2379 (1993), Fontanini, G., et al.: Clin. Cancer Res., 4, 241 (1998), Comis, R., et al.: Oncologist, 10, 467 (2005), Ling, J., et al.: Drug Metab. Dispos., 34, 420 (2006),

Formula: C₂₁₂H₄H₁₇N₃O₄

Color and Shape: Neat

Molecular weight: 383.43

Ref: TR-O702252