CAS 121662-14-4

(+/-)-IBUPROFEN-D3

Description:

(+/-)-Ibuprofen-D3 is a deuterated form of ibuprofen, a widely used nonsteroidal anti-inflammatory drug (NSAID) known for its analgesic, antipyretic, and anti-inflammatory properties. The "D3" designation indicates that this compound contains three deuterium atoms, which are isotopes of hydrogen, replacing standard hydrogen atoms in the ibuprofen structure. This modification can enhance the stability and metabolic tracking of the molecule in pharmacokinetic studies. The compound retains the core characteristics of ibuprofen, including its mechanism of action, which involves the inhibition of cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins. This results in reduced pain and inflammation. The deuterated version is often utilized in research settings to study drug metabolism and pharmacodynamics without interference from the non-deuterated form. As with other forms of ibuprofen, safety and efficacy are paramount, and it is important to consider potential side effects and contraindications associated with NSAIDs.

Formula: C₁₃H₁₅D₃O₂

InChI: InChI=1/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/i3D3

SMILES: CC(C)Cc1ccc(cc1)C(C([2H])([2H])[2H])C(=O)O

Synonyms:

• (+/-)-Ibuprofen-D3 (Alpha-Methyl-D3)
• Ibuprofen-Methyl-D3
• 2-(4-Isobutylphenyl)propionic Acid-d3
• rac Ibuprofen-d3
• α-Methyl-d3-4-(isobutyl)phenylacetic acid
• (+/-)-IBUPROFEN-D3
• IBUPROFEN-D3
• Ibuprofen D3 (Racemic)

Ibuprofen-d3

CAS: 121662-14-4

Formula: C₁₃H₁₅D₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 209.30

Ref: 4Z-I-041

Ibuprofen-D3

CAS: 121662-14-4

Ibuprofen-D3

Purity: 98%

Molecular weight: 209.3g/mol

Ref: 54-DE2124

(+/-)-Ibuprofen-d3(α-methyl-d3)

CAS: 121662-14-4

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 209.30

Ref: 3U-D6119

Ibuprofen D3 (α-methyl D3)

Controlled Product

CAS: 121662-14-4

Formula: C₁₃H₃H₁₅O₂

Color and Shape: Neat

Molecular weight: 209.30

Ref: 04-C14278100

Ibuprofen-d3

CAS: 121662-14-4

Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor (IC50s: 13 μM and 370 μM).

Formula: C₁₃H₁₈O₂

Color and Shape: Solid

Molecular weight: 209.3

Ref: TM-T11604

Ibuprofen-D3

Controlled Product

CAS: 121662-14-4

Applications Labelled Ibuprofen, a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.
References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),

Formula: C₁₃₂H₃H₁₅O₂

Color and Shape: Off-White

Molecular weight: 209.3

Ref: TR-I140002

Benzeneacetic acid, α-(methyl-d3)-4-(2-methylpropyl)- (9CI)

CAS: 121662-14-4

Formula: C₁₃H₁₅D₃O₂

Purity: %

Color and Shape: Solid

Molecular weight: 209.2993

Ref: IN-DA0015JK