CAS 1216665-49-4

2,4-Pyrimidinediamine, N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-

CAS: 1216665-49-4

Formula: C₁₇H₁₆N₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 332.3625

Ref: IN-DA0015J5

APY29

CAS: 1216665-49-4

APY29

Purity: ≥95%

Molecular weight: 332.36g/mol

Ref: 54-BUP13073

N2-(1H-Benzo[D]Imidazol-6-Yl)-N4-(5-Cyclopropyl-1H-Pyrazol-3-Yl)Pyrimidine-2,4-Diamine

CAS: 1216665-49-4

N2-(1H-Benzo[D]Imidazol-6-Yl)-N4-(5-Cyclopropyl-1H-Pyrazol-3-Yl)Pyrimidine-2,4-Diamine

Purity: 98%

Molecular weight: 332.36g/mol

Ref: 54-OR1023219

APY29

CAS: 1216665-49-4

APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.

Formula: C₁₇H₁₆N₈

Purity: 96.51% - 98.46%

Color and Shape: Solid

Molecular weight: 332.36

Ref: TM-T3654

APY29 Hydrochloride Salt

Controlled Product

CAS: 1216665-49-4

Applications APY29 Hydrochloride Salt is an hydrochloride salt of APY29 (A735420), which is a modulator of inositol requiring enzyme IRE1α, a protein sited in the endoplasmic recticulum that has kinase and RNase activities triggered by endoplasmic recticulum stress. It also functions in the allosteric control of IRE1α endoribonuclease using kinase inhibitors for the development of drugs for endoplasmic recticulum stress related diseases.
References Wang, L., et al.: Nat. Chem. Biol.,8, 982 (2012);

Formula: C₁₇H₁₆N₈•x(HCl)

Color and Shape: Neat

Molecular weight: 332.363646

Ref: TR-A735422

APY29

CAS: 1216665-49-4

APY29 is a fatty acid that belongs to the group of polyunsaturated fatty acids. It regulates the transcriptional activity of genes related to body formation and has been shown to have anticancer properties. APY29 has also been shown to be an effective drug for treating autoimmune diseases, such as rheumatoid arthritis and psoriasis, by affecting the inflammatory response pathway in cells. This compound binds to toll-like receptor 4 (TLR4), which is a protein that recognizes bacterial products and initiates an immune response. The TLR4 binding site on APY29 was found to be necessary for its effect on TLR4 activation.

Formula: C₁₇H₁₆N₈

Purity: Min. 95%

Molecular weight: 332.36 g/mol

Ref: 3D-RYB66549