CAS 1216744-19-2

1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

CAS: 1216744-19-2

Formula: C₁₈H₂₁ClN₂O₄S

Purity: 99%

Color and Shape: Solid

Molecular weight: 396.8883

Ref: IN-DA009CI5

GSK4112

CAS: 1216744-19-2

GSK4112

Purity: ≥98%

Molecular weight: 396.89g/mol

Ref: 54-BUP11293

GSK4112

CAS: 1216744-19-2

GSK4112 (SR6452) is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.

Formula: C₁₈H₂₁ClN₂O₄S

Purity: 99.69%

Color and Shape: Solid

Molecular weight: 396.89

Ref: TM-T5045

GSK4112

CAS: 1216744-19-2

GSK4112 is a novel, orally bioavailable compound that is being developed for the treatment of metabolic disorders and bowel diseases. GSK4112 inhibits the production of tumor necrosis factor-α (TNF-α) and other pro-inflammatory cytokines in vitro, as well as downregulates toll-like receptor 4 (TLR4) expression in vivo. GSK4112 has been shown to protect 3T3-L1 preadipocytes from induced apoptosis and reduce the size of fat cells without affecting their viability. These effects are due to increased autophagy and decreased lipid accumulation. The oral bioavailability of GSK4112 was found to be high in vivo.

Formula: C₁₈H₂₁ClN₂O₄S

Purity: Min. 95%

Molecular weight: 396.89 g/mol

Ref: 3D-RYB74419