CAS 1216770-08-9

NABUMETONE-D3

Description:

Nabumetone-D3 is a deuterated form of nabumetone, a nonsteroidal anti-inflammatory drug (NSAID) primarily used for the treatment of osteoarthritis and rheumatoid arthritis. As a deuterated compound, it contains deuterium, an isotope of hydrogen, which can enhance its stability and alter its pharmacokinetic properties. The chemical structure of nabumetone features a naphthalene ring and a ketone functional group, contributing to its anti-inflammatory effects by inhibiting cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins. Nabumetone-D3 is often utilized in pharmacokinetic studies to trace the drug's metabolism and distribution in biological systems. Its characteristics include a relatively long half-life, which allows for once-daily dosing, and it is generally well-tolerated, with a side effect profile similar to other NSAIDs. The use of deuterated compounds like nabumetone-D3 in research can provide insights into drug behavior and interactions, aiding in the development of more effective therapeutic agents.

Formula: C₁₅H₁₃D₃O₂

Synonyms:

• 3-one
• 2H3]-Nabumetone
• NABUMETONE-D3
• 4-[6-(trideuteriomethoxy)naphthalen-2-yl]butan-2-one
• 4-[6-(Methoxy-d3)-2-naphthyl]butan-2-one
• 4-[6-(Methoxy-d3)-naphthalen-2-yl]butan-2-one
• 1-(2'-Methoxy-d3-naphth-6'-yl)butan-
• 4-[6-(Methoxy-d3)-2-naphthalenyl]-2-butanone

Nabumetone-d3

CAS: 1216770-08-9

Formula: C₁₅H₁₃D₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 231.31

Ref: 4Z-N-182

Nabumetone-d3 (methoxy-d3)

CAS: 1216770-08-9

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 231.31

Ref: 3U-D7156

Nabumetone-d3

Controlled Product

CAS: 1216770-08-9

Applications Labelled Nabumetone. Anti-inflammatory. Antibacterial.
References Kumpulainen, H., et al.: J. Med. Chem., 49, 1207 (2006),

Formula: C₁₅₂H₃H₁₃O₂

Color and Shape: Neat

Molecular weight: 231.30

Ref: TR-N200502