CAS 121679-13-8

Naratriptan

Description:

Naratriptan is a selective agonist for the serotonin 5-HT_1B and 5-HT_1D receptors, primarily used in the treatment of migraine headaches. It belongs to the triptan class of medications, which are designed to alleviate migraine symptoms by constricting dilated blood vessels in the brain and inhibiting the release of pro-inflammatory neuropeptides. Naratriptan is characterized by its relatively long half-life compared to other triptans, which allows for sustained relief from migraine symptoms. It is typically administered orally and is known for its favorable side effect profile, including a lower incidence of rebound headaches. The chemical structure of naratriptan includes a naphthalene ring, contributing to its pharmacological properties. Its solubility is moderate, and it is metabolized primarily in the liver, with renal excretion of its metabolites. As with other triptans, naratriptan is contraindicated in patients with cardiovascular conditions due to the potential for vasoconstriction. Overall, naratriptan is an effective option for managing acute migraine attacks, providing relief for many patients.

Formula: C₁₇H₂₅N₃O₂S

InChI: InChI=1S/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H3

InChI key: InChIKey=AMKVXSZCKVJAGH-UHFFFAOYSA-N

SMILES: C(CS(NC)(=O)=O)C=1C=C2C(=CNC2=CC1)C3CCN(C)CC3

Synonyms:

• N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide
• N-Methyl-3-(1-methyl-4-piperidyl)indole-5-ethanesulfonamide
• Naratriptan
• 1H-Indole-5-ethanesulfonamide, N-methyl-3-(1-methyl-4-piperidinyl)-

N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethane-1-sulfonamide

CAS: 121679-13-8

Formula: C₁₇H₂₅N₃O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 335.4643

Ref: IN-DA0015K1

Naratriptan

CAS: 121679-13-8

Formula: C₁₇H₂₅N₃O₂S

Color and Shape: Off-White To Pale Yellow Solid

Molecular weight: 335.47

Ref: 4Z-N-271

Naratriptan

CAS: 121679-13-8

Naratriptan

Purity: ≥98%

Molecular weight: 335.47g/mol

Ref: 54-BUP02958

Naratriptan-13C-d3

CAS: 121679-13-8

Formula: C₁₇H₂₂N₃O₂SD₃

Molecular weight: 339.49

Ref: 4Z-N-273

Naratriptan

CAS: 121679-13-8

Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches.

Formula: C₁₇H₂₅N₃O₂S

Purity: 99.08%

Color and Shape: Solid

Molecular weight: 335.47

Ref: TM-T8666

Naratriptan-d7

CAS: 121679-13-8

Formula: C₁₇H₁₈N₃O₂SD₇

Molecular weight: 342.51

Ref: 4Z-N-274

Naratriptan

Controlled Product

CAS: 121679-13-8

Applications Naratriptan is a triptan drug that is used for the treatment of migraine headaches.
References Dulery, B.D., et al.: J. Pharm. Biomed. Anal., 15, 1009 (1997), Havanka, H., et al.: Clin. Ther., 22, 970 (2000),

Formula: C₁₇H₂₅N₃O₂S

Color and Shape: Neat

Molecular weight: 335.464

Ref: TR-N378760

Naratriptan

CAS: 121679-13-8

Naratriptan is a non-steroidal anti-inflammatory drug that belongs to the group of triptans. Naratriptan has been shown to be effective against migraine headaches, although its efficacy may depend on the individual's susceptibility to side effects. This drug has been shown to bind to 5HT receptors in rat ileum and vas deferens, which are involved in the physiological effects of naratriptan. Naratriptan also inhibits the release of inflammatory mediators such as histamine and serotonin from mast cells and platelets, respectively. Naratriptan has been shown to cause cardiac abnormalities such as tachycardia and hypertension in rats. These adverse effects have not been observed in humans, but it is possible that they may occur at higher doses or in certain populations (e.g., children).

Formula: C₁₇H₂₅N₃O₂S

Purity: Min. 95%

Molecular weight: 335.47 g/mol

Ref: 3D-FN170148