CAS 121695-87-2

SARAFOTOXIN S6C

Description:

Sarafotoxin S6C is a peptide toxin derived from the venom of certain species of snakes, particularly those in the family Viperidae. It is known for its potent biological activity, primarily as a neurotoxin that affects the cardiovascular system. Sarafotoxin S6C exhibits high affinity for specific receptors, leading to vasoconstriction and increased blood pressure. Its structure typically includes a series of amino acids arranged in a specific sequence, contributing to its stability and activity. The toxin is often studied for its potential implications in pharmacology and toxicology, as it can provide insights into receptor interactions and signaling pathways. Additionally, due to its biological effects, Sarafotoxin S6C is of interest in research related to hypertension and other cardiovascular disorders. Safety precautions are essential when handling this substance, as it can pose significant health risks. Overall, Sarafotoxin S6C serves as a valuable model for understanding the mechanisms of peptide toxins and their potential therapeutic applications.

Formula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

InChI: InChI=1/C103H147N27O37S5/c1-10-46(6)80(100(163)123-67(103(166)167)30-50-37-109-54-19-15-14-18-52(50)54)128-99(162)79(45(4)5)127-95(158)66(36-78(144)145)120-85(148)55(20-23-71(105)133)112-90(153)61(31-51-38-108-43-110-51)117-97(160)69-40-170-169-39-53(104)83(146)129-81(47(7)131)102(165)126-70-42-172-171-41-68(96(159)115-59(28-44(2)3)88(151)118-62(32-72(106)134)91(154)116-60(89(152)125-69)29-49-16-12-11-13-17-49)124-86(149)57(22-25-75(138)139)111-84(147)56(21-24-74(136)137)113-94(157)65(35-77(142)143)122-101(164)82(48(8)132)130-87(150)58(26-27-168-9)114-93(156)64(34-76(140)141)121-92(155)63(33-73(107)135)119-98(70)161/h11-19,37-38,43-48,53,55-70,79-82,109,131-132H,10,20-36,39-42,104H2,1-9H3,(H2,105,133)(H2,106,134)(H2,107,135)(H,108,110)(H,111,147)(H,112,153)(H,113,157)(H,114,156)(H,115,159)(H,116,154)(H,117,160)(H,118,151)(H,119,161)(H,120,148)(H,121,155)(H,122,164)(H,123,163)(H,124,149)(H,125,152)(H,126,165)(H,127,158)(H,128,162)(H,129,146)(H,130,150)(H,136,137)(H,138,139)(H,140,141)(H,142,143)(H,144,145)(H,166,167)

SMILES: CCC(C)C(C(=NC(Cc1c[nH]c2ccccc12)C(=O)O)O)N=C(C(C(C)C)N=C(C(CC(=O)O)N=C(C(CCC(=N)O)N=C(C(Cc1cnc[nH]1)N=C(C1CSSCC(C(=NC(C(C)O)C(=NC2CSSCC(C(=NC(CC(C)C)C(=NC(CC(=N)O)C(=NC(Cc3ccccc3)C(=N1)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CCC(=O)O)N=C(C(CC(=O)O)N=C(C(C(C)O)N=C(C(CCSC)N=C(C(CC(=O)O)N=C(C(CC(=N)O)N=C2O)O)O)O)O)O)O)O)O)O)N)O)O)O)O)O

Synonyms:

• Srtx-C
• Sarafotoxin S6C (Atractaspis Engaddensis)
• Sarafotoxin S6C, Atractaspsis Engaddensis
• Sarafotoxin 6C
• Sarafotoxin C
• Sarafotoxin C (Atractaspis Engaddensis)
• Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp

Sarafotoxin C

CAS: 121695-87-2

Highly selective ET-B receptor agonist.

Formula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Purity: > 95%

Color and Shape: White Powder

Molecular weight: 2515.79

Ref: 01-4031255

Sarafotoxin S6c

CAS: 121695-87-2

Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).

Formula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 2516

Ref: TM-TP2120

Sarafotoxin S6c

CAS: 121695-87-2

Formula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Purity: ≥ 95.0%

Color and Shape: White lyophilised powder

Molecular weight: 2515.75

Ref: 7W-GK0055

Sarafotoxin S6c

CAS: 121695-87-2

Sarafotoxin S6c, sourced from the venom of the Atractaspis engaddensis snake family, is one of four (S6a-d) isopeptides of the Sarafotoxins. This product is a synthetically produced toxin, containing disulfide bonds between Cys1-Cys15 and Cys3-Cys11.
Due to their structural and functional homology to the endothelin peptides, Sarafotoxins can enhance vasoconstriction through stimulating the class A G-protein-coupled, endothelin ETA and ETB receptors. This in turn leads to left ventricular dysfunction and bronchoconstriction. Compared to the sarafotoxin isopeptide S6b, S6c is less toxic with a 100 to 10,000-fold reduced affinity for the ETA receptor, therefore acts as a selective agonist to the ETB receptor. One study demonstrated that when sarafotoxin 6c was used to activate ETB receptors in rats there was an increase in arterial pressure, known as S6c-induced hypertension.
As the upregulation of Endothelin-1 (ET-1) is related to circulatory-system diseases, the interaction between ET-1 and its receptors is highly important for development of endothelin receptor antagonist treatments. Sarafotoxin S6c can be used as a pharmacological reagent to study these interactions.

Formula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Purity: Min. 95%

Molecular weight: 2,515.8 g/mol

Ref: 3D-PSF-4246-S

Sarafotoxin C trifluoroacetate salt

CAS: 121695-87-2

Sarafotoxin C is a peptide from the venom of the spider Phoneutria nigriventer that has been shown to have potent inhibitory properties on endothelin-1. Sarafotoxin C is able to block intracellular Ca2+ levels and signal pathways, leading to decreased levels of endothelin-1 as well as other inflammatory mediators. Sarafotoxin C has also been shown to have an anti-inflammatory effect in bowel disease, which may be due to its ability to inhibit the production of cytokines and prostaglandins. The biological properties of sarafotoxin C are related to its inhibition of polymerase chain reaction (PCR) amplification of DNA. This inhibition is due to the binding of sarafotoxin C with endothelin receptors on DNA, which prevents DNA polymerase from attaching. Endothelin-a receptor activity can also be inhibited by sarafotoxin C through enzymatic inactivation. Sarafot

Formula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Purity: Min. 95%

Molecular weight: 2,515.76 g/mol

Ref: 3D-FS110267