CAS 1217247-62-5

N-Desethyl Sunitinib-d5

Controlled Product

CAS: 1217247-62-5

Applications A labelled metabolite of Sunitinib (S820000).
References Sun, L., et al.: J. Med. Chem., 46, 1116 (2003), Mendel, D.B., et al.: Clin. Cancer Res., 9, 327 (2003), Sistla, A., et al.: Drug Dev. Ind. Pharm., 30, 19 (2004), Sakamoto, K.M., et al.: Curr. Opin. Invest. Drugs, 5. 1329 (2004),

Formula: C₂₀H₁₈D₅FN₄O₂

Color and Shape: Neat

Molecular weight: 375.45

Ref: TR-D289652

N-Desethyl sunitinib-d5

CAS: 1217247-62-5

Sunitinib is a drug that is used to treat renal cell cancer. It is a tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme, which prevents the activation of the protein. Sunitinib has been shown to be effective against metastatic renal cell cancer and can be used with other drugs such as docetaxel or paclitaxel. Sunitinib's active metabolite, N-desethyl sunitinib, has also been shown to have similar effects on kidney cancer cells as its parent compound. Monitoring blood levels of sunitinib and its metabolites may help determine an individualized dose for each patient.

Formula: C₂₀H₂₃FN₄O₂

Purity: Min. 95%

Molecular weight: 375.5 g/mol

Ref: 3D-SYB24762