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CAS 1217452-48-6

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N-(9-Fluorenylmethoxycarbonyl)-L-proline-13C5,15N, L-Proline-13C5,15N, N-Fmoc derivative

Description:
N-(9-Fluorenylmethoxycarbonyl)-L-proline-13C5,15N, commonly referred to as an Fmoc derivative of L-proline, is a modified amino acid used primarily in peptide synthesis and research. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is crucial for the selective protection of the amino group during peptide assembly. The presence of isotopes, specifically carbon-13 (13C) and nitrogen-15 (15N), allows for advanced analytical techniques such as NMR spectroscopy, aiding in the study of molecular dynamics and interactions. The Fmoc group can be easily removed under basic conditions, facilitating the sequential addition of amino acids in solid-phase peptide synthesis. This derivative maintains the fundamental properties of proline, including its role in influencing peptide conformation due to its unique cyclic structure. The compound is typically utilized in the synthesis of peptides with specific isotopic labeling, which is valuable in various biochemical and pharmaceutical applications. Overall, its characteristics make it a versatile tool in the field of synthetic chemistry and biochemistry.
Formula:C20H19NO4
Synonyms:
  • N-(9-Fluorenylmethoxycarbonyl)-L-proline-13C5,15N, L-Proline-13C5,15N, N-Fmoc derivative
  • [U-13C5,15N]-Fmoc-Pro-OH
  • Fmoc-Pro-OH-13C5,15N
  • Fmoc-Pro-OH(C13,N15)
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