(2S)-OMPT, or (2S)-2-(4-methoxyphenyl)-2-(thiazol-2-yl)thiazolidine-4-carboxylic acid, is a chemical compound characterized by its specific stereochemistry and functional groups. It features a thiazolidine ring, which is a five-membered heterocyclic structure containing sulfur and nitrogen atoms, contributing to its biological activity. The presence of a methoxyphenyl group enhances its lipophilicity, potentially influencing its interaction with biological membranes and receptors. This compound is of interest in medicinal chemistry, particularly for its potential pharmacological properties. Its stereochemistry, denoted by the (2S) configuration, is crucial for its biological activity, as many biological interactions are stereospecific. Additionally, the thiazole moiety may play a role in its reactivity and interaction with various biological targets. Overall, (2S)-OMPT represents a class of compounds that may exhibit significant therapeutic potential, warranting further investigation into its mechanisms of action and applications in drug development.

Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors -
LPA
1
/EDG-
2, LPA
2
/EDG-
4, LPA
3
/EDG-
7 and LPA
4
/GPR23.
1
,
2
OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA
3
) receptor. It exhibits EC
50
values of 68 nM and >6.8 μM for calcium mobilization in LPA
1
and LPA
2
-
expressing Sf9 cells, respectively.
3
The (2S)-
OMPT enantiomer is 5-
to 20-
fold more active than (2R)-
OMPT in calcium release assays in both LPA
3
-
transfected Sf9 and rat hepatoma Rh7777 cells.
4

(2S)-OMPT

1217471-69-6: (2S)-OMPT, or (2S)-2-(4-methoxyphenyl)-2-(thiazol-2-yl)thiazolidine-4-carboxylic acid, is a chemical compound characterized by its specific stereochemistry and functional groups. It features a thiazolidine ring, which is a five-membered heterocyclic structure containing sulfur and nitrogen atoms, contributing to its biological activity. The presence of a methoxyphenyl group enhances its lipophilicity, potentially influencing its interaction with biological membranes and receptors. This compound is of interest in medicinal chemistry, particularly for its potential pharmacological properties. Its stereochemistry, denoted by the (2S) configuration, is crucial for its biological activity, as many biological interactions are stereospecific. Additionally, the thiazole moiety may play a role in its reactivity and interaction with various biological targets. Overall, (2S)-OMPT represents a class of compounds that may exhibit significant therapeutic potential, warranting further investigation into its mechanisms of action and applications in drug development.

<p>(2S)-OMPT (triethylamine), in ethanol:chloroform (1:1), 98%</p>

CAS 1217471-69-6

(2S)-OMPT

(2S)-OMPT (triethylamine), in ethanol:chloroform (1:1), 98%

Ref: 54-OR1075475