CAS 1217623-80-7

DILTIAZEM-D3 HYDROCHLORIDE

Description:

Diltiazem-D3 hydrochloride is a deuterated form of diltiazem, a calcium channel blocker primarily used in the treatment of hypertension and certain types of angina. As a hydrochloride salt, it is typically more soluble in water, enhancing its bioavailability. The deuteration (D3) indicates the presence of deuterium, a stable isotope of hydrogen, which can influence the compound's pharmacokinetics and metabolic stability. Diltiazem works by inhibiting calcium ions from entering cardiac and smooth muscle cells, leading to vasodilation and reduced heart rate. This compound is characterized by its ability to relax blood vessels, decrease myocardial oxygen demand, and improve exercise tolerance in patients with angina. In terms of physical properties, it is usually presented as a white to off-white crystalline powder. Safety and handling precautions are essential, as with all pharmaceuticals, to mitigate potential side effects and interactions. Overall, Diltiazem-D3 hydrochloride serves as a valuable tool in cardiovascular therapy, with research ongoing to explore its full potential and applications.

Formula: C₂₂H₂₄ClD₃N₂O₄S

Synonyms:

• DILTIAZEM-D3 HYDROCHLORIDE
• Zilden-D3)
• Masdil-d3
• CRD-401-d3
• Dilzem-d3
• (2S,cis)-3-(Acetyloxy)-5-[(2-dimethylamino-d3)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride
• Adizem-d3
• Zilden-d
• Altiazem-d3

Diltiazem-d3 Hydrochloride

Controlled Product

CAS: 1217623-80-7

Applications Labelled Diltiazem (D460620). A calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).
References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971), Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998), Hansson, L., et al.: Lancet, 356, 359 (2000),

Formula: C₂₂H₂₄D₃ClN₂O₄S

Color and Shape: Neat

Molecular weight: 454.0

Ref: TR-D460622

Diltiazem-d3 hydrochloride

CAS: 1217623-80-7

Diltiazem-d3 is a high purity, water soluble form of diltiazem. Diltiazem-d3 is an inhibitor of phosphodiesterase (PDE) and an activator of potassium channels. It has been used in research as a tool to study the interaction between PDEs and potassium channels.

Formula: C₂₂H₂₇ClN₂O₄S

Purity: Min. 95%

Molecular weight: 454 g/mol

Ref: 3D-SYB62380

Diltiazem-d3 Hydrochloride

CAS: 1217623-80-7

Formula: C₂₂H₂₄ClD₃N₂O₄S

Purity: CP：98%

Color and Shape: Solid

Molecular weight: 453.9973

Ref: IN-DA01CBXQ