CAS 1217651-73-4

COLCHICINE-D6

Description:

Colchicine-D6 is a deuterated form of colchicine, a well-known alkaloid derived from the plant Colchicum autumnale, commonly used in medicine for its anti-inflammatory properties and its role in treating gout and familial Mediterranean fever. The "D6" designation indicates that six hydrogen atoms in the colchicine molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification can enhance the substance's utility in research, particularly in studies involving metabolic pathways and pharmacokinetics, as deuterated compounds often exhibit different behavior in biological systems compared to their non-deuterated counterparts. Colchicine itself acts by inhibiting microtubule polymerization, thereby affecting cell division and inflammatory processes. The CAS number 1217651-73-4 uniquely identifies this specific deuterated variant, facilitating its recognition in scientific literature and databases. As with any chemical substance, handling colchicine-D6 requires caution due to its biological activity, and it should be used in accordance with safety guidelines and regulations.

Formula: C₂₂H₁₉D₆NO₆

Synonyms:

• Colchineos-d6
• N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide-d6
• Colsaloid-d6
• COLCHICINE-D6
• Condylon-d6
• Colcin-d6
• NSC 757-d6
• Colchisol-d6

Colchicine-d6

CAS: 1217651-73-4

Formula: C₂₂H₁₉D₆NO₆

Color and Shape: Yellow Solid

Molecular weight: 405.48

Ref: 4Z-C-151

2-Demethyl Colchicine Glucuronide Sodium Salt

CAS: 1217651-73-4

Formula: C₂₇H₃₀NO₁₂·Na

Color and Shape: Yellow Solid

Molecular weight: 561.55

Ref: 4Z-C-1510

Colchicine-d6

Controlled Product

CAS: 1217651-73-4

Formula: C₂₂H₁₉D₆NO₆

Color and Shape: Solid

Molecular weight: 405.472

Ref: TR-C640003

Colchicine-d6

CAS: 1217651-73-4

Colchicine-d6 is an analog of colchicine that has been deuterated at the C-ring. It is a potent inhibitor of tubulin polymerization and has been shown to induce apoptosis in various cancer cell lines. Colchicine-d6 inhibits kinases such as protein kinase C and glycogen synthase kinase-3β, which are involved in the regulation of apoptosis. It also inhibits xylanases, which are enzymes that degrade hemicellulose in plant cell walls. Colchicine-d6 has anticancer properties and can be used as an inhibitor for cancer treatment. Its efficacy has been demonstrated in Chinese hamster ovary cells and human urinary tumor cells. This compound shows promise as a potential therapeutic agent for the treatment of various cancers.

Formula: C₂₂H₂₅NO₆

Purity: Min. 95%

Molecular weight: 405.5 g/mol

Ref: 3D-SYB65173