CAS 1217676-37-3

Aprepitant-13C2,d2 (Major)

Controlled Product

CAS: 1217676-37-3

Applications This product is deuterated at the 1 position and on the ajacent methyl. The 1 position is the benylic position of the bis(trifluoromethyl) phenyl. This compound has a mixture of 1 to 4 deuterium atoms, there is no detectable unlabeled material.Aprepitant is a structurally novel substance P neurokinin 1 (NK1) receptor antagonist. In vitro studies using human liver microsomes indicate that aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1.
References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006),

Formula: C₂₁₁₃C₂H₁₉D₂F₇N₄O₃

Color and Shape: Off White Solid

Molecular weight: 538.42

Ref: TR-A729802

Aprepitant-13C2,d2

CAS: 1217676-37-3

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Formula: C₂₃H₂₁F₇N₄O₃

Purity: Min. 95%

Molecular weight: 538.4 g/mol

Ref: 3D-SYB67637