CAS 1217731-56-0

Abacavir-d4 (cyclopropyl-2,2,3,3-d4)

CAS: 1217731-56-0

Purity: 99 atom % D

Molecular weight: 290.36

Ref: 3U-D8039

Abacavir-d4

Controlled Product

CAS: 1217731-56-0

Stability Very Hygroscopic
Applications Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Formula: C₁₄H₁₄D₄N₆O

Color and Shape: Off-White

Molecular weight: 290.36

Ref: TR-A105002

Abacavir-d4

Controlled Product

CAS: 1217731-56-0

Abacavir-d4 is a deuterium-labeled analogue of the antiretroviral medication Abacavir. It serves as a critical tool for pharmaceutical research and development. This isotopically labeled compound is synthesized by incorporating four deuterium atoms into the molecular structure of Abacavir, preserving the pharmacokinetic and pharmacodynamic properties of the original molecule while allowing for precise analytical quantification.

Formula: C₁₄H₁₄D₄N₆O

Purity: Min. 95%

Molecular weight: 290.36 g/mol

Ref: 3D-SYB73156