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CAS 1217748-67-8

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Ezetimibe Hydroxy tert-Butyldiphenylsilyl Ether

Description:
Ezetimibe Hydroxy tert-Butyldiphenylsilyl Ether is a chemical compound primarily recognized for its role in pharmacology, particularly in the treatment of hyperlipidemia. It is a derivative of Ezetimibe, which functions by inhibiting the absorption of cholesterol in the intestines. This compound features a hydroxy group and a tert-butyldiphenylsilyl ether moiety, which contributes to its solubility and stability. The presence of the silyl ether group enhances its lipophilicity, potentially improving its bioavailability. Ezetimibe itself is known for its selective action on the Niemann-Pick C1-like 1 (NPC1L1) protein, which is crucial for cholesterol uptake. The compound is typically characterized by its molecular structure, which includes carbon, hydrogen, oxygen, and silicon atoms. Its physical properties, such as melting point, boiling point, and solubility, are influenced by the presence of the bulky silyl group. Overall, Ezetimibe Hydroxy tert-Butyldiphenylsilyl Ether represents a significant advancement in lipid-lowering therapies, with ongoing research into its pharmacokinetics and therapeutic efficacy.
Formula:C40H39F2NO3Si
Synonyms:
  • Ezetimibe Hydroxy tert-Butyldiphenylsilyl Ether
  • (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-tert-butyldiphenylsilyloxy -3-(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone
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