CAS 1217749-86-4

Atorvastatin-d5 Lactone

Controlled Product

CAS: 1217749-86-4

Applications Labelled Atorvastatin intermediate as inhibitor of MAP kinase and/or HMG-CoA reductase for the treatment of inflammation.
References Boyd, R., et al.: J. Clin. Pharmacol., 40, 91, (2000), Bogman, K., et al.: Br. J. Pharmacol., 132, 1183 (2001), Backman, J., et al.: Clin. Pharmacol. Ther., 72, 685 (2002), Kalvass, J., et al.: Drug Metab. Dispos., 35, 455 (2007),

Formula: C₃₃H₂₈D₅FN₂O₄

Color and Shape: Neat

Molecular weight: 545.66

Ref: TR-A791782

Atorvastatin-d5 lactone

CAS: 1217749-86-4

Atorvastatin-d5 lactone is an outpatient medication that belongs to the group of statins. It is a prodrug that is hydrolyzed in vivo to atorvastatin, its active form. Atorvastatin-d5 lactone has been shown to inhibit the production of creatine kinase (CK) in wild-type mice and knockout mice with a defective uptake of creatine. This drug also inhibits the uptake of creatine by muscle cells and reduces CK levels in serum. The clinical studies have demonstrated that this drug can be used for diagnosis and management of patients with hypercholesterolemia or other lipid disorders.

Formula: C₃₃H₃₃FN₂O₄

Purity: Min. 95%

Molecular weight: 545.7 g/mol

Ref: 3D-SYB74986