CAS 1218-34-4

Acetyl-L-tryptophan

Description:

Acetyl-L-tryptophan is a derivative of the amino acid tryptophan, characterized by the addition of an acetyl group to its nitrogen atom. This modification enhances its solubility and bioavailability compared to its parent compound. The substance is typically a white to off-white crystalline powder and is soluble in water and organic solvents, making it useful in various biochemical applications. Acetyl-L-tryptophan is known for its potential role in neurotransmitter synthesis, particularly serotonin, and may influence mood and sleep regulation. It is often studied for its effects on cognitive function and as a dietary supplement. Additionally, it may exhibit antioxidant properties and has been investigated for its potential therapeutic applications in conditions such as depression and anxiety. As with many amino acid derivatives, it is important to consider its safety profile and dosage when used in supplements or research. Overall, Acetyl-L-tryptophan serves as an important compound in both nutritional and pharmaceutical contexts.

Formula: C₁₃H₁₄N₂O₃

InChI: InChI=1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1

InChI key: InChIKey=DZTHIGRZJZPRDV-LBPRGKRZSA-N

SMILES: C([C@H](NC(C)=O)C(O)=O)C=1C=2C(NC1)=CC=CC2

Synonyms:

• (2S)-2-Acetamido-3-(1H-indol-3-yl)propanoic acid
• (S)-N-Acetyltryptophan
• <span class="text-smallcaps">L</span>-N-Acetyltryptophan
• <span class="text-smallcaps">L</span>-Tryptophan, N-acetyl-
• Ac-L-Trp-OH
• Acetyl-<span class="text-smallcaps">L</span>-tryptophan
• Acetyltryptophan
• N-Acetyl-<span class="text-smallcaps">L</span>-tryptophan
• N-Acetyl-L-Tryptophan
• N-acetyltryptophan
• N-α-Acetyl-L-Tryptophan
• NSC 90726
• Tryptophan, N-acetyl-, <span class="text-smallcaps">L</span>-
• L-Tryptophan, N-acetyl-
• Acetyl-L-tryptophan
• Tryptophan, N-acetyl-, L-

N-Acetyl-L-tryptophan

CAS: 1218-34-4

Formula: C₁₃H₁₄N₂O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light red powder to crystal

Molecular weight: 246.27

Ref: 3B-A0121

N-Acetyl-L-tryptophan, 99%

CAS: 1218-34-4

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₃H₁₄N₂O₃

Purity: 99%

Color and Shape: White to off-white powder

Molecular weight: 246.27

Ref: 02-J64096

Ac-Trp-OH

CAS: 1218-34-4

The NK1 receptor antagonist Ac-Trp (L-NAT) inhibits the secretion of substance P and IL-1β. L-NAT reduced dyskinesia in a hemi-parkinsonian rodent model.

Formula: C₁₃H₁₄N₂O₃

Purity: > 99%

Color and Shape: Whitish Powder

Molecular weight: 246.27

Ref: 01-4003876

N-ACETYLTRYPTOPHAN CRS

CAS: 1218-34-4

N-ACETYLTRYPTOPHAN CRS

Formula: C₁₃H₁₄N₂O₃

Molecular weight: 246.2619

Ref: 41-A0208000

Tryptophan Related Compound B (2-Acetamido-3-(1H-indol-3-yl)propanoic acid)

CAS: 1218-34-4

Aromatic or modified aromatic heterocyclic compounds withnitrogen hetero-atom(s) only nesoi

Formula: C₁₃H₁₄N₂O₃

Color and Shape: White Off-White Colorless Crystalline Powder Crystals

Molecular weight: 246.29

Ref: 45-1700523

L-Tryptophan, N-acetyl-

CAS: 1218-34-4

Formula: C₁₃H₁₄N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 246.2619

Ref: IN-DA001627

N-Acetyl-L-tryptophan

CAS: 1218-34-4

N-Acetyl-L-tryptophan

Purity: ≥98%

Molecular weight: 246.26g/mol

Ref: 54-BUP19215

N-Acetyl-L-tryptophan

CAS: 1218-34-4

Formula: C₁₃H₁₄N₂O₃

Purity: ≥ 98.5%

Color and Shape: White to almost white powder

Molecular weight: 246.30

Ref: 7W-GM7304

N-Acetyltryptophan

Controlled Product

CAS: 1218-34-4

Formula: C₁₃H₁₄N₂O₃

Color and Shape: Neat

Molecular weight: 246.26

Ref: 86-MM0172.13

N-Acetyl-L-tryptophan

CAS: 1218-34-4

N-Acetyl-L-tryptophan

Purity: 99%

Color and Shape: Solid

Molecular weight: 246.26g/mol

Ref: 54-BIA1792

N-Acetyl-L-tryptophan

CAS: 1218-34-4

N-Acetyl-L-tryptophan (N-acetyltryptophan) is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).

Formula: C₁₃H₁₄N₂O₃

Purity: 99.93%

Color and Shape: Solid

Molecular weight: 246.26

Ref: TM-T8789

Tryptophan USP Related Compound B (N-Acetyl-L-Tryptophan)

CAS: 1218-34-4

Formula: C₁₃H₁₄N₂O₃

Molecular weight: 246.27

Ref: 4Z-T-2019

N-Acetyl-L-Tryptophan

Controlled Product

CAS: 1218-34-4

Applications N-Acetyl-L-Tryptophan, is a derivative of L-Tryptophan (T947210), that can be used as competitive inhibitor to identify and characterize tryptophanases. It can also be used as an NK1 tachykinin receptor antagonist, that may help to develop a novel therapeutic intervention for the treatment of reperfusion injury in acute ischemic stroke.
References Turner, R. J., et al.: Neuroscience, 220, 1 (2012);

Formula: C₁₃H₁₄N₂O₃

Color and Shape: White To Off-White

Molecular weight: 246.26

Ref: TR-A168730

N-Acetyl-L-tryptophan

CAS: 1218-34-4

N-Acetyl-L-tryptophan is a neuroprotective agent that binds to the group p2 receptor for neurokinin-1 (NK-1) and inhibits the apoptosis pathway. It is used in the treatment of Parkinson's disease, Alzheimer's disease, and Huntington's disease. N-Acetyl-L-tryptophan has been shown to inhibit inflammatory lesions in rats with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. This drug also interacts with toll-like receptor 4 (TLR4), which activates downstream signaling cascades involving NFκB, MAP kinase, and JAK/STAT pathways. The molecular docking analysis revealed that N-acetyl tryptophan binds to specific sites on TLR4 and prevents its activation by preventing binding of LPS.

Formula: C₁₃H₁₄N₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 246.26 g/mol

Ref: 3D-FA37435

N-Acetyl-L-Tryptophan extrapure, 99%

CAS: 1218-34-4

Formula: C₁₃H₁₄N₂O₃

Purity: min. 99%

Color and Shape: Off - white to pale brown, Powder, Clear

Molecular weight: 246.3

Ref: SR-11644

N-Acetyl-L-Tryptophan ExiPlus, Multi-Compendial, 99%

CAS: 1218-34-4

Formula: C₁₃H₁₄N₂O₃

Purity: min. 99%

Color and Shape: Off white to pale brown, Powder, Clear

Molecular weight: 246.3

Ref: SR-48861

Ac-Trp-OH

CAS: 1218-34-4

M03025 - Ac-Trp-OH

Formula: C₁₃H₁₄N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 246.266

Ref: 10-M03025

Tryptophan USP Related Compound B

CAS: 1218-34-4

Formula: C₁₃H₁₄N₂O₃

Molecular weight: 246.27

Ref: ST-EA-CP-T90020