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CAS 121864-74-2

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carbovir triphosphate

Description:
Carbovir triphosphate, with the CAS number 121864-74-2, is a nucleotide analog that serves as an important antiviral agent, particularly in the treatment of HIV. It is a phosphorylated form of carbovir, which is a derivative of the nucleoside cytidine. The triphosphate form is crucial for its mechanism of action, as it competes with natural nucleotides for incorporation into viral DNA during reverse transcription. This incorporation leads to chain termination, effectively inhibiting viral replication. Carbovir triphosphate exhibits a high affinity for the viral reverse transcriptase enzyme, making it a potent inhibitor. Its chemical structure includes a ribose sugar, a carbocyclic base, and three phosphate groups, which contribute to its stability and efficacy. The compound is typically administered in conjunction with other antiretroviral therapies to enhance treatment outcomes. Due to its specific action on viral enzymes, carbovir triphosphate is a valuable tool in the management of HIV infections, showcasing the importance of nucleotide analogs in antiviral drug development.
Formula:C11H16N5O11P3
InChI:InChI=1/C11H16N5O11P3/c12-11-14-9-8(10(17)16(11)18)13-5-15(9)7-2-1-6(3-7)4-28(19,20)26-30(24,25)27-29(21,22)23/h1-2,5-7,18H,3-4H2,(H2,12,14)(H,19,20)(H,24,25)(H2,21,22,23)/t6-,7+/m0/s1
Synonyms:
  • Triphosphoric acid, P-((4-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-2-cyclopenten-1-yl)methyl) ester, cis-(+-)-
  • triphosphoric acid, mono[[(1S,4R)-4-(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)-2-cyclopenten-1-yl]methyl] ester
  • [(1R,4S)-4-(2-amino-1-hydroxy-6-oxo-purin-9-yl)-1-cyclopent-2-enyl]methyl-(hydroxy-phosphonooxy-phosphoryl)oxy-phosphinic acid
  • Carbovir triphosphate
  • Triphosphoric acid, p-[[4-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-2-cyclopenten-1-yl]methyl] ester, cis-(1)-
  • Aids001909
  • (+/-)-cis-2-Amino-1,9-dihydro-9-[4-oxymethyltriphosphate-2-cyclopenten-1-yl-]purine-6-one
  • Aids-001909
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