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CAS 1218948-84-5

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Valacyclovir hydrochloride hydrate

Description:
Valacyclovir hydrochloride hydrate is an antiviral medication primarily used to treat infections caused by certain types of viruses, including herpes simplex virus and varicella-zoster virus. It is the L-valyl ester of acyclovir, which enhances its bioavailability when administered orally. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for formulation in various dosage forms. Its chemical structure includes a valine moiety, which contributes to its pharmacokinetic properties. Valacyclovir is converted to acyclovir in the body, where it exerts its antiviral effects by inhibiting viral DNA synthesis. The hydrochloride salt form enhances stability and solubility. As a hydrate, it contains water molecules in its crystalline structure, which can affect its physical properties and stability. Valacyclovir is generally well-tolerated, but like all medications, it may have side effects and contraindications that should be considered during treatment.
Formula:C13H20N6O4·ClH·xH2O
InChI:InChI=1S/C13H20N6O4.ClH.H2O/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20;;/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20);1H;1H2/t8-;;/m0../s1
InChI key:InChIKey=KNOVZDRKHSHEQN-JZGIKJSDSA-N
SMILES:C(OCCOC([C@H](C(C)C)N)=O)N1C2=C(N=C1)C(=O)N=C(N)N2.Cl.O
Synonyms:
  • L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester, hydrochloride, hydrate (1:1:?)
  • Valacyclovir hydrochloride hydrate
  • Valaciclovir hydrochloride hydrate
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