CAS 121917-57-5

(-)-MK-801 MALEATE

Description:

(-)-MK-801 maleate, with the CAS number 121917-57-5, is a potent non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, which plays a crucial role in synaptic plasticity and memory function. This compound is primarily utilized in neuroscience research to study the effects of NMDA receptor inhibition on various neurological conditions, including neurodegenerative diseases and psychiatric disorders. As a maleate salt, it is typically more soluble in water than its base form, facilitating its use in biological experiments. The compound exhibits a high affinity for the NMDA receptor, leading to significant effects on excitatory neurotransmission. Its stereochemistry, indicated by the prefix "(-)", suggests that it is the levorotatory form, which is essential for its biological activity. Due to its potent effects, (-)-MK-801 maleate is often used in animal models to investigate the mechanisms underlying cognitive functions and the potential therapeutic effects of NMDA receptor modulation. However, caution is advised due to its potential neurotoxic effects at high doses.

Formula: C₂₀H₁₉NO₄

InChI: InChI=1/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t15-,16+;/m1./s1

Synonyms:

• (5S,10R)-(-)-5-Methyl-10,11-Dihydro-5H-Dibenzo[A,D]Cyclohepten-5,10-Imine Maleate
• (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene (2E)-but-2-enedioate

(−)-MK-801 (maleate)

CAS: 121917-57-5

Formula: C₂₀H₁₉NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 337.3692

Ref: IN-DA009AIW

(-)-Dizocilpine maleate

CAS: 121917-57-5

(-)-Dizocilpine maleate

Purity: ≥98%

Molecular weight: 337.37g/mol

Ref: 54-BUP06939

(-)-Dizocilpine maleate

CAS: 121917-57-5

(-)-Dizocilpine maleate ((-)-MK 801 (Maleate)) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

Formula: C₂₀H₁₉NO₄

Purity: >99.99%

Color and Shape: White Solid

Molecular weight: 337.37

Ref: TM-T6352

(-)-MK 801 Maleate

Controlled Product

CAS: 121917-57-5

Applications (-)-MK 801 Maleate was used in biological study to observe antipsychotics and other agents effects on prepulse inhibition of acoustic startle in rats. Binding properties of (-)-MK 801 Maleate, NMDA receptor channel blocker, were characterized in different brain regions
References Johansson, C, et al.: Pharmacol, Biochem. Behav., 52, 649 (1995); Bresink, I., et al.: Neuropharmacology, 34, 533 (1995);

Formula: C₁₆H₁₅N·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 221.30 + 116.07

Ref: TR-M425048

(-)-MK 801 maleate

CAS: 121917-57-5

NMDA antagonist, less active enantiomer

Formula: C₁₆H₁₅N·C₄H₄O₄

Purity: Min. 95%

Molecular weight: 337.37 g/mol

Ref: 3D-FM157164