CAS 122018-58-0

PLP (139-151)

Description:

PLP, or pyridoxal phosphate, is the active form of vitamin B6 and plays a crucial role as a coenzyme in various biochemical reactions, particularly in amino acid metabolism. It is characterized by its ability to participate in transamination, decarboxylation, and racemization reactions, facilitating the conversion of amino acids and the synthesis of neurotransmitters. The substance is a yellow crystalline powder that is soluble in water and exhibits a pH-dependent stability profile, being more stable at neutral to slightly alkaline conditions. PLP is essential for the proper functioning of enzymes involved in the metabolism of carbohydrates, lipids, and amino acids, making it vital for numerous physiological processes. Deficiency in PLP can lead to various health issues, including anemia and neurological disorders. Its CAS number, 122018-58-0, identifies it uniquely in chemical databases, aiding in research and regulatory contexts. Overall, PLP is a significant biochemical compound with diverse roles in human health and metabolism.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Synonyms:

• Proteolipid Protein
• Myelin Proteolipid Protein Fragment (139-151)
• (Ser140)-Myelin Proteolipid Protein (139-151), Depalmitoylated, Human, Bovine, Dog, Mouse, Rat
• [Ser140]-Myelin Proteolipid Protein (139-151) (Human, Bovine, Dog, Mouse, Rat)
• H2N-Hslgkwlghpdkf-Oh

(Ser¹⁴⁰)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat)

CAS: 122018-58-0

This fragment of myelin proteolipid protein is an encephalitogenic determinant, able to bind to diverse sets of T cell receptors.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Purity: 97.0%

Color and Shape: White

Molecular weight: 1521.74

Ref: 01-4030575

[SER140]-PLP(139-151)

CAS: 122018-58-0

[SER140]-PLP(139-151) is a polypeptide fragment of the lipid protein of myelin.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 1521.72

Ref: TM-TP1312

PLP (139-151)

CAS: 122018-58-0

PLP (139-151) is derived from Proteolipid Protein (PLP), an epitope of immunodominant encephalitogenic PLP and is involved in promoting encephalomyelitis.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,520.8 g/mol

Ref: 3D-CRB1000865

PLP (139-151)

CAS: 122018-58-0

PLP (139-151) peptide is a fragment of myelin proteolipid protein (PLP or lipophilin), from amino acid residue 139 to 151 (HCLGKWLGHPDKF – CAS 131334-43-5 ). Myelin proteolipid protein is the major myelin protein from the central nervous system. PLP (139-151) peptide is commonly used to induce experimental autoimmune encephalomyelitis (EAE) in SJL/J mice. The PLP (139-151) peptide C140S is mutant of the wild-type version where the cystein is replaced by a serine to make the peptide more stable without impacting its antigenic activity.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Molecular weight: 1,521.7 g/mol

Ref: 3D-PP50157

Myelin PLP (139-151)

CAS: 122018-58-0

Myelin PLP (139-151) is a basic protein that belongs to the family of oligodendrocyte-myelin glycoproteins. It has been shown to activate toll-like receptor, which is a pattern recognition receptor that recognizes invading pathogens and triggers an immune response. Myelin PLP (139-151) may play a role in the development of autoimmune diseases, as it has been found to be a target for autoantibodies. It has also been shown to have antioxidative properties, which may help prevent free radical damage in the brain and other tissues. The monoclonal antibody against this protein can be used for immunohistological analysis.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Purity: Min. 95%

Molecular weight: 1,521.72 g/mol

Ref: 3D-PLP-3812-PI

Myelin PLP (139-151) acetate

CAS: 122018-58-0

Myelin PLP (139-151) acetate salt is a cyclic peptide that is derived from the sequence of human myelin basic protein and contains the sequence PLP (139-151). This peptide has shown to have antioxidative properties. It has been shown to have an inhibitory effect on the production of proinflammatory cytokines in experimental autoimmune encephalomyelitis (EAE), which is a model for multiple sclerosis. The peptide has also been shown to block signal pathways, such as toll-like receptor 4, and decrease Ca2+ overload. Clinical relevance remains unclear.

Formula: C₇₂H₁₀₄N₂₀O₁₇•(C₂H₄O₂)x

Purity: Min. 95%

Molecular weight: 1,521.76 g/mol

Ref: 3D-PLP-3602-PI

(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt

CAS: 122018-58-0

Ser140-Myelin Proteolipid Protein (139-151) is an experimental autoimmune encephalomyelitis (EAE) adjuvant that is used to induce EAE in animals. The peptide has been shown to be mononuclear, encephalitogenic, and capable of inducing cell proliferation. Ser140-Myelin Proteolipid Protein (139-151) has been shown to induce EAE when injected into the animals with a pre-existing immunity to myelin basic protein. Ser140-Myelin Proteolipid Protein (139-151) is also mannosylated and can be used as an experimental adjuvant for immunization.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Purity: Min. 95%

Molecular weight: 1,521.72 g/mol

Ref: 3D-FS108682