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CAS 122028-36-8

:

Dorzolomide hydrochloride

Description:
Dorzolamide hydrochloride is a carbonic anhydrase inhibitor primarily used in the treatment of elevated intraocular pressure in conditions such as glaucoma and ocular hypertension. It is a white to off-white crystalline powder that is soluble in water and exhibits a pH range of approximately 4.5 to 6.5 in solution. The compound works by inhibiting the enzyme carbonic anhydrase, which reduces the production of aqueous humor in the eye, thereby lowering intraocular pressure. Dorzolamide hydrochloride is typically administered as an eye drop solution, and its pharmacokinetics involve local absorption with minimal systemic effects. The substance is known for its relatively low side effect profile, although some patients may experience ocular discomfort, burning, or stinging upon application. It is important to note that dorzolamide should be used with caution in patients with renal impairment or those on other carbonic anhydrase inhibitors. Overall, dorzolamide hydrochloride is a valuable therapeutic agent in managing specific eye conditions.
Formula:C10H17ClN2O4S3
InChI:InChI=1/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1
SMILES:CCN[C@H]1C[C@H](C)S(=O)(=O)c2c1cc(s2)S(=O)(=O)N.Cl
Synonyms:
  • 3-B)Thiopyran-2-Sulfonamide,5,6-Dihydro-4-(Ethylamino)-6-Methyl-4H-Thieno(
  • Mk-0507
  • Monohydrochloride,(4S-Trans)-7-Dioxide
  • (2S,4S)-2-Ethylamino-4-Methyl-5,5-Dioxo-5,7-Dithiabicyclo[4.3.0]Nona-8,10-Diene-8-Sulfonamide Hydrochloride
  • Dorzolamide Hcl
  • Dorzolamide Hydrochloride
  • DorzolomideHcl,Usp
  • (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride
  • Dorzalamide hydrochloride
  • Dorzolomide  HCL
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Found 5 products.