CAS 1221423-80-8

Cyclo(L-alanyl-L-lysyl-D-prolyl-L-prolyl-L-threonyl-L-tryptophyl-L-leucyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-tryptophyl-L-lysyl-L-lysyl)

Description:

Cyclo(L-alanyl-L-lysyl-D-prolyl-L-prolyl-L-threonyl-L-tryptophyl-L-leucyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-tryptophyl-L-lysyl-L-lysyl) is a cyclic peptide characterized by its complex structure, which consists of a sequence of amino acids linked in a cyclic manner. This cyclic arrangement often enhances the stability and bioactivity of peptides compared to their linear counterparts. The presence of various amino acids, including both L- and D-forms, contributes to its unique properties, potentially influencing its interactions with biological targets. Cyclization can also affect solubility, permeability, and resistance to enzymatic degradation, making such peptides of interest in pharmaceutical applications. The specific sequence of amino acids may impart unique biological activities, such as antimicrobial, anticancer, or neuroprotective effects, depending on the context of their use. Additionally, the CAS number 1221423-80-8 serves as a unique identifier for this compound, facilitating its identification in chemical databases and literature.

Formula: C₈₇H₁₄₁N₂₇O₁₅

Synonyms:

• Cyclo(L-alanyl-L-lysyl-D-prolyl-L-prolyl-L-threonyl-L-tryptophyl-L-leucyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-tryptophyl-L-lysyl-L-lysyl)

Cyclic L27-11

CAS: 1221423-80-8

Cyclic L27-11 is a cyclic peptide analog antibiotic that exhibits potent antimicrobial activity against specific bacteria, particularly Pseudomonas sp. It is highly effective against Pseudomonas aeruginosa, demonstrating nanomolar-level antibacterial activity. The mechanism of action for Cyclic L27-11 involves interfering with the function of the bacterial outer membrane protein LptD, inhibiting the normal transport of lipopolysaccharide (LPS). This inhibition leads to the accumulation of membrane-like substances within the bacterial cell, adversely affecting bacterial survival. Consequently, Cyclic L27-11 is a promising candidate for antimicrobial agent development.

Formula: C₈₇H₁₄₁N₂₇O₁₅

Color and Shape: Solid

Molecular weight: 1805.22

Ref: TM-TP2754