CAS 122194-07-4

DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE

Description:

Dimethyl N,N-diisopropylphosphoramidite is a chemical compound commonly used in the field of organic synthesis, particularly in the synthesis of oligonucleotides. It is characterized by its phosphoramidite functional group, which consists of a phosphorus atom bonded to two isopropyl groups and a dimethylamino group. This structure imparts unique reactivity, making it a valuable reagent for the phosphorylation of nucleosides. The compound is typically a colorless to pale yellow liquid and is known for its relatively low volatility. It is sensitive to moisture and air, which can lead to hydrolysis and degradation, necessitating careful handling and storage under inert conditions. Dimethyl N,N-diisopropylphosphoramidite is also recognized for its ability to form stable phosphodiester bonds, making it essential in the synthesis of DNA and RNA sequences. Safety precautions are important when working with this compound, as it may pose health risks if inhaled or ingested, and appropriate personal protective equipment should be used.

Formula: C₈H₂₀NO₂P

Synonyms:

• Dimethyl-N,N-Diisopropylphosphoroamidite

Phosphoramidous acid, N,N-bis(1-methylethyl)-, dimethyl ester

CAS: 122194-07-4

Formula: C₈H₂₀NO₂P

Purity: 97%

Color and Shape: Liquid

Molecular weight: 193.2237

Ref: IN-DA0016XA

Dimethyl n,n-diisopropylphosphoramidite

CAS: 122194-07-4

Dimethyl n,n-diisopropylphosphoramidite

Formula: C₈H₂₀NO₂P

Purity: 97%

Color and Shape: colourless liquid

Molecular weight: 193.22g/mol

Ref: 54-OR963457

Dimethyl N,N-diisopropylphosphoramidite

Controlled Product

CAS: 122194-07-4

Dimethyl N,N-diisopropylphosphoramidite is a phosphoramidite compound that is used to synthesize peptides. Dimethyl N,N-diisopropylphosphoramidite can be used to synthesize hydrophobic sequences, as well as sequences with functional groups such as hydroxyl or amine. It has been shown that the dimethyl phosphoramidite group protects the free radical of tetrazole in the synthesis of tetrazolide. Dimethyl N,N-diisopropylphosphoramidite is also an anion and a molecule. This compound has been commercialized for use in coatings and contraceptives. Dimethyl N,N-diisopropylphosphoramidite is often used in peptide synthesis reactions because it can react with threonine, which is a non-essential amino acid found in many proteins. The kinetics of

Formula: C₈H₂₀NO₂P

Purity: Min. 95%

Color and Shape: Colorless Clear Liquid

Molecular weight: 193.22 g/mol

Ref: 3D-FD22252

Dimethyl-N,N-diisopropylphosphoramidite

CAS: 122194-07-4

Formula: C₈H₂₀NO₂P

Purity: 97%

Color and Shape: Liquid

Molecular weight: 193.227

Ref: 10-F493278

Dimethyl N,N-Diisopropylphosphoramidite-d6

Controlled Product

CAS: 122194-07-4

Applications Dimethyl N,N-Diisopropylphosphoramidite-d6 is an isotope labelled reagent for the efficient phosphorylation of alcohols.
References Tatsumi, S., et al.: Tetrahedron. Lett., 54, 3731 (2013);

Formula: C₈D₆H₁₄NO₂P

Color and Shape: Neat

Molecular weight: 199.261

Ref: TR-D472502

Dimethyl N,N-Diisopropylphosphoramidite

Controlled Product

CAS: 122194-07-4

Stability Moisture Sensitive
Applications A useful reagent for the efficient phosphorylation of alcohols.
References Perich, J.W., et al.: Synthesis, 142 (1988)

Formula: C₈H₂₀NO₂P

Color and Shape: Neat

Molecular weight: 193.22

Ref: TR-D472500