The chemical substance known as (3R)-N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine, with the CAS number 1221973-93-8, is a complex organic compound characterized by its unique spirocyclic structure. This compound features a bicyclic framework that includes an azabicyclo structure, which contributes to its potential biological activity. The presence of an imidazole and a pyrimidine moiety suggests that it may interact with biological targets, possibly as a ligand or inhibitor in various biochemical pathways. The specific stereochemistry indicated by the (3R) designation implies that the compound has a defined three-dimensional arrangement, which is crucial for its interaction with biological systems. Additionally, the oxazole ring adds to the compound's heterocyclic nature, potentially influencing its solubility and reactivity. Overall, this compound may have applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific diseases or conditions.

BMS-933043 is a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia. BMS-933043 showed potent binding affinity to native rat (Ki = 3.3 nM) and recombinant human alpha7 nicotinic acetylcholine receptors (Ki = 8.1 nM) and agonist activity in a calcium fluorescence assay (EC50 = 23.4 nM) and whole cell voltage clamp electrophysiology (EC50 = 0.14 micromolar (rat) and 0.29 micromolar (human)). BMS-933043 showed no agonist or antagonist activity at other nicotinic acetylcholine receptor subtypes and was at least 300 fold weaker at binding to and antagonizing human 5-HT3A receptors (Ki = 2,451 nM; IC50 = 8,066 nM).

(3R)-N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine

1221973-93-8: The chemical substance known as (3R)-N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine, with the CAS number 1221973-93-8, is a complex organic compound characterized by its unique spirocyclic structure. This compound features a bicyclic framework that includes an azabicyclo structure, which contributes to its potential biological activity. The presence of an imidazole and a pyrimidine moiety suggests that it may interact with biological targets, possibly as a ligand or inhibitor in various biochemical pathways. The specific stereochemistry indicated by the (3R) designation implies that the compound has a defined three-dimensional arrangement, which is crucial for its interaction with biological systems. Additionally, the oxazole ring adds to the compound's heterocyclic nature, potentially influencing its solubility and reactivity. Overall, this compound may have applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific diseases or conditions.

BMS-933043: α7 nAChR partial agonist, binds rat (Ki=3.3 nM) & human (Ki=8.1 nM), agonist with EC50=23.4 nM (calcium assay), 0.14-0.29 μM (electrophysiology).

CAS 1221973-93-8

(3R)-N-[6-(1H-Imidazol-1-yl)-4-pyrimidinyl]spiro[1-azabicyclo[2.2.2]octane-3,5'(4'H)-oxazol]-2'-amine

BMS-933043

Ref: TM-T26865