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CAS 122254-45-9

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Glenvastatin

Description:
Glenvastatin, identified by its CAS number 122254-45-9, is a synthetic compound belonging to the class of statins, which are primarily used to manage cholesterol levels in the body. Statins function by inhibiting the enzyme HMG-CoA reductase, a key player in the biosynthesis of cholesterol in the liver. Glenvastatin is characterized by its ability to lower low-density lipoprotein (LDL) cholesterol and triglycerides while potentially raising high-density lipoprotein (HDL) cholesterol levels. This compound exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a relatively long half-life, allowing for once-daily dosing. Additionally, Glenvastatin may possess anti-inflammatory and antioxidant properties, contributing to cardiovascular health beyond cholesterol management. As with other statins, common side effects may include muscle pain, liver enzyme alterations, and gastrointestinal disturbances. It is essential for patients to consult healthcare professionals for appropriate monitoring and management while on this medication.
Formula:C27H26FNO3
InChI:InChI=1S/C27H26FNO3/c1-17(2)27-23(13-12-22-14-21(30)15-26(31)32-22)24(18-8-10-20(28)11-9-18)16-25(29-27)19-6-4-3-5-7-19/h3-13,16-17,21-22,30H,14-15H2,1-2H3/b13-12+/t21-,22-/m1/s1
InChI key:InChIKey=LJIZUXQINHXGAO-ITWZMISCSA-N
SMILES:C(=C/[C@@H]1C[C@@H](O)CC(=O)O1)\C=2C(=CC(=NC2C(C)C)C3=CC=CC=C3)C4=CC=C(F)C=C4
Synonyms:
  • (4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one
  • 2H-Pyran-2-one, 6-[(1E)-2-[4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethenyl]tetrahydro-4-hydroxy-, (4R,6S)-
  • Glenvastin
  • 2H-Pyran-2-one, 6-[2-[4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethenyl]tetrahydro-4-hydroxy-, [4R-[4α,6β(E)]]-
  • HR 780
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