CAS 1222998-36-8

Torin1

Description:

Torin1 is a small molecule inhibitor primarily known for its role in targeting the mechanistic target of rapamycin (mTOR), a crucial regulator of cell growth, proliferation, and survival. It is characterized by its ability to selectively inhibit both mTORC1 and mTORC2 complexes, making it a valuable tool in research related to cancer, metabolic disorders, and aging. Torin1 is often utilized in studies investigating the pathways of autophagy and cellular metabolism, as it can induce autophagy under certain conditions. The compound is typically administered in a laboratory setting and is soluble in organic solvents, which facilitates its use in various biochemical assays. Its effectiveness and specificity make it a significant compound in pharmacological research, particularly in the development of therapeutic strategies targeting mTOR signaling pathways. However, like many experimental drugs, its safety and efficacy in clinical settings require further investigation.

Synonyms:

• CS-1958
• Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-
• 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one
• mTOR Inhibitor XI, Torin1 - Calbiochem

Torin 1

CAS: 1222998-36-8

Formula: C₃₅H₂₈F₃N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 607.6243

Ref: IN-DA009CF5

Torin 1

CAS: 1222998-36-8

Torin 1

Purity: ≥98%

Molecular weight: 607.62g/mol

Ref: 54-BUP04738

Torin 1

CAS: 1222998-36-8

Formula: C₃₅H₂₈F₃N₅O₂

Molecular weight: 607.64

Ref: 4Z-K-031017

Torin 1

CAS: 1222998-36-8

Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.

Formula: C₃₅H₂₈F₃N₅O₂

Purity: 98.3% - 99.33%

Color and Shape: Solid

Molecular weight: 607.62

Ref: TM-T6045

Torin 1

Controlled Product

CAS: 1222998-36-8

Applications Torin 1 is a potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34.
References Thoreen, et al.: J. Biol. Chem., 284, 8023 (2009), Liu, et al.: J. Med. Chem., 53, 7146 (2010), Peterson, et al.: Peterson, et al.: Cell, 146 408 (2011),

Formula: C₃₅H₂₈F₃N₅O₂

Color and Shape: Neat

Molecular weight: 607.62

Ref: TR-T548700

Torin 1

CAS: 1222998-36-8

mTOR inhibitor

Formula: C₃₅H₂₈F₃N₅O₂

Purity: Min. 95%

Molecular weight: 607.62 g/mol

Ref: 3D-FT103463